阿司匹林联合低分子肝素钙及地屈孕酮对习惯性流产患者妊娠结局的价值体会

Value of Aspirin Combined with Low Molecular Weight Heparin Calcium and Dydrogesterone in Pregnancy Outcomes in Patients with Habitual Abortion

目的探究阿司匹林联合低分子肝素钙及地屈孕酮对习惯性流产患者妊娠结局的治疗价值。方法方便选取2016年9月-2017年9月期间于该院接受治疗的86例习惯性流产患者为研究对象,以数字随机方式分为对照组和研究组,每组43例患者。对照组患者以肌肉注射黄体酮、人绒毛膜促性腺激素方式治疗,研究组以阿司匹林、肝素、地屈孕酮联合治疗,观察治疗后各项指标的水平,对比两组的妊娠结局。结果治疗后各项指标对比,研究组PT、APTT、IL-4水平明显上升,且上升状况优于对照组,D-二聚体、IFN-γ明显降低,降低程度明显优于对照组,各项指标研究组更优,差异有统计学意义(P<0.05)。两组患者妊娠结局对比,研究组无死胎和畸形新生儿,早产3例,流产5例,足月生产35例,胎儿活产38例,活产率为88.37%,对照组死胎1例,无畸形新生儿,早产6例,流产9例,足月生产27例,胎儿活产33例,活产率为76.74%,两组活产率对比,差异有统计学意义(χ^2=6.339,P=0.012)。结论阿司匹林、肝素、地屈孕酮联合治疗习惯性流产,获得了满意的治疗效果。

Objective To investigate the therapeutic value of aspirin combined with low molecular weight heparin calcium and dydrogesterone in the pregnancy outcome of patients with habitual abortion. Methods From September 2016 to September 2017, 86 patients with habitual abortion who were treated in our hospital were enrolled in the study. They were convenient divided into the control group and the study group, with 43 patients in each group. The patients in the control group were treated with intramuscular injection of progesterone and human chorionic gonadotropin. The study group was treated with aspirin, heparin and dydrogesterone. The levels of various indicators after treatment were observed and the pregnancy outcomes of the two groups were compared. Results After treatment, the levels of PT, APTT and IL-4 in the study group increased significantly, and the increase condition was better than that of the control group. D-dimer and IFN-γ were significantly lower than the control group. The index study group was better, and the difference was statistically significant (P<0.05). The pregnancy outcomes of the two groups were compared. The study group had no stillbirth and malformation neonates, 3 cases of premature delivery, 5 cases of abortion, 35 cases of full-term production, 38 cases of live birth, the live birth rate was 88.37%, and 1 case of stillbirth malformed neonates, 6 cases of premature delivery, 9 cases of abortion, 27 cases of full-term production, 33 cases of live birth, the live birth rate was 76.74% in the control group, the live birth rate of the two groups,the difference was statistically significant(χ^2=6.339,P=0.012). Conclusion Aspirin, heparin and dydrogesterone in combination with habitual abortion have achieved satisfactory therapeutic effects.