根除Hp后消化性溃疡患者复发的影响因素分析

Analysis of influencing factors on recurrence of peptic ulcer patients after eradication of Hp

目的探讨分析根除幽门螺杆菌(Hp)后消化性溃疡的复发影响因素。方法选取296例消化性溃疡患者,均进行Hp根除治疗,治疗后对其进行为期18个月的跟踪随访,统计患者的复发情况,对其性别、年龄、居住情况、生活规律情况进行分析,评价其复发的影响因素。结果 296例患者纳入研究对象,随访18个月, 11例患者因失访或退出终止观察,共285例完成随访终点,其中男192例,女93例;平均年龄(43.40±8.53)岁;36例患者复发消化性溃疡,复发率为12.63%。复发患者与未复发患者的性别、平均年龄及睡眠不规律、饮食不规律、应激状态、不良饮食习惯、服用非甾体类消炎药(NSAIDs)、吸烟发生率比较,差异均无统计学意义(P>0.05);249例未复发患者中独居64例、多家庭成员居住185例, 36例复发患者中独居3例、多家庭成员居住33例,比较差异具有统计学意义(P<0.05);249例未复发患者中集体进餐174例(69.88%), 36例复发患者中集体进餐33例(91.67%),比较差异具有统计学意义(P<0.05);249例未复发患者中Hp再感染11例(4.42%), 36例复发患者中Hp再感染10例(27.78%),比较差异具有统计学意义(P<0.05)。多家庭成员居住、集体进餐、Hp再感染是根除Hp后消化性溃疡患者复发的影响因素。结论根除Hp后消化性溃疡复发的影响因素包括Hp再感染、集体进餐、多家庭成员居住等。

Objective To discuss and analyze the influencing factors on recurrence of peptic ulcer patients after eradication of Helicobacter pylori (Hp). Methods All 296 patients with peptic ulcer were treated with Hp eradication, and they were followed up for 18 months after treatment. The recurrence status of peptic ulcer patients was counted. Their gender, age, living conditions and living rules were analyzed to evaluate the influencing factors of recurrence. Results There were 296 patients included in the study, and 11 patients were terminated due to loss to follow-up or withdrawal after 18 months of follow-up. A total of 285 patients completed the follow-up, including 192 males and 93 females, with average age as (43.40± 8.53) years old. 36 patients had recurrent peptic ulcer, with a recurrence rate of 12.63%. There were no significant differences in gender, average age, irregular sleep, irregular diet, stress state, bad eating habits, taking non-steroidal anti-inflammatory drugs (NSAIDs) and smoking rates between between recurrence cases and non-recurrence cases (P>0.05). Among 249 non-recurrence cases, 64 cases were living alone, 185 cases were living with multiple family members. Among 36 recurrence cases, 3 cases were living alone and 33 cases were living with multiple family members. The difference was statistically significant (P<0.05). There were 174 cases (69.88%) had group meals in 249 non-recurrence cases, and 33 cases (91.67%) had group meals in 36 recurrence cases. The difference was statistically significant (P<0.05). There were 174 cases (69.88%) had group meals in 249 non-recurrence cases, and 33 cases (91.67%) had group meals in 36 recurrence cases. The difference was statistically significant (P<0.05). There were 11 cases (4.42%) had reinfection of Hp in 249 non-recurrence cases, and 10 cases (27.78%) had reinfection of Hp in 36 recurrence cases. The difference was statistically significant (P<0.05). Univariate analysis showed that multiple family members living, group meals and Hp reinfection were the influencing factors of peptic ulcer recurrence. Conclusion The influencing factors of recurrence of peptic ulcer after eradication of Hp include Hp infection, group meals and multi-family residence.