叉头转录因子1/3在肝纤维化中的作用

Role of FOXO1/3 in the pathogenesis of hepatic fibrosis

肝纤维化是指各种致病因子所致肝内结缔组织异常增生的病理过程。肝纤维化伴随于肝损伤修复愈合的全过程,慢性长期的损伤因素会诱导纤维化进展成肝硬化。流行病学数据显示,2017年我国共报告乙型肝炎新发病例118.05万、丙型肝炎24.3万。慢性病毒性肝炎带来了沉重的社会经济负担。叉头转录因子(FOXO)从属于叉头状家族,在细胞的各项生命活动中发挥着重要作用。研究发现,FOXO1/3可通过TGFβ通路调节肝星状细胞活力,在肝纤维化病变中扮演着重要角色。综述了肝纤维化病变机制、FOXO1/3对肝纤维化的调控机制,以及FOXO1/3(肝纤维化病变位点之一)的靶向治疗研究进展。

Hepatic fibrosis refers to the pathological process of abnormal proliferation of connective tissue in the liver caused by various pathogenic factors. Hepatic fibrosis is observed in the whole process of liver injury repair and healing, and long-term chronic injury factors may induce the progression of hepatic fibrosis into liver cirrhosis. Epidemiological data show that there are 1.1805 million new cases of hepatitis B and 243 thousand cases of hepatitis C reported in 2017. Chronic viral hepatitis has brought heavy social and economic burden. Forkhead transcription factor (FOXO) belongs to the forkhead family and plays an important role in various cell life activities. Studies have shown that FOXO1/3 can regulate hepatic stellate cell activity through the TGFβ pathway and thus play an important role in hepatic fibrosis. This article reviews the research advances in the pathogenesis of hepatic fibrosis, the mechanism of action of FOXO1/3 in the regulation of hepatic fibrosis, and targeted therapy for FOXO1/3 (one of the sites for hepatic fibrosis).