苯巴比妥联合肠道益生菌治疗新生儿黄疸的疗效观察

Curative Effect Observation of Phenobarbital Combined with Intestinal Probiotics in the Treatment of Neonatal Jaundice

目的探讨苯巴比妥联合肠道益生菌治疗新生儿黄疸(neonatal jaundice,NJ)的疗效。方法选取2015年1月至2018年1月阳新县人民医院NJ患儿200例,依据随机数字表法分为试验组和对照组,每组100例;对照组给予对症治疗和苯巴比妥治疗,试验组在此基础上给予肠道益生菌治疗;比较2组肠黏膜功能[内毒素(endotoxin,ET)、二胺氧化酶(diamine oxidase,DAO)、D-乳酸(D-lactic acid,D-LA)]、胆红素、退黄时间、治疗有效率、不良反应发生率。结果与治疗前比较,试验组和对照组治疗后ET、DAO、D-LA降低,且试验组治疗后ET、DAO、D-LA明显低于对照组(P<0.05);与治疗前比较,试验组和对照组治疗后胆红素降低,且试验组治疗后胆红素、退黄时间明显低于对照组(P<0.05);试验组治疗有效率明显高于对照组(P<0.05);试验组和对照组不良反应发生率基本相同,差异无统计学意义。结论苯巴比妥联合肠道益生菌治疗可有效改善NJ患儿肠黏膜功能和胆红素水平,有利于提高疗效,且具有良好的安全性,值得临床作进一步推广。

OBJECTIVE To discuss the curative effect of phenobarbital combined with intestinal probiotics in the treatment of neonatal jaundice(NJ). METHODS Two hundred children with NJ were selected from January 2015 to January 2018 in Yangxin People's Hospital, they were divided in to test group and control group by the random number table method, 100 cases in each group. The control group was given symptomatic treatment and phenobarbital treatment, the test group was given intestinal probiotics treatment on the basis of control group. The difference of the intestinal mucosal function[endotoxin(ET), diamine oxidase(DAO), D-lactic acid(D-LA)], bilirubin, yellowing time, therapeutic effect, adverse reaction rate in the two groups were compared. RESULTS Compared with before treatment, the ET, DAO, D-LA were decreased in the test group and the control group after treatment, and the ET, DAO, D-LA in the test group were significantly lower than those in the control group after treatment(P<0.05). Compared with before treatment, the bilirubin level were decreased in the test group and the control group after treatment, and the bilirubin level and yellowing time in the test group were significantly lower than those in the control group after treatment(P<0.05). The therapeutic efficiency rate in the test group was significantly higher than that in the control group(P<0.05). The adverse reaction rate were basically the same in the test group and control group, the difference was not statistically significant. CONCLUSION Phenobarbital combined with intestinal probiotics can effectively improve the intestinal mucosal function and bilirubin level in children with NJ, it is helpful to improve the curative effect, and it has good safety, it is worth for further clinical promotion.