血清降钙素原在脓毒症临床诊断中的应用研究

Clinical value of serum procalcitonin in diagnosis of sepsis

目的对比分析血清降钙素原(PCT)与炎性因子C-反应蛋白(CRP)、白介素-6(IL-6)及血清淀粉样蛋白A(SAA)在脓毒症患者早期诊断中的应用价值。方法分析2016年7月-2017年10月医院重症医学科接受诊治的42例脓毒症患者(观察组)的临床资料。另外选取同期在医院接受健康体检的46例健康者作为本次研究的对照组。比较两组患者的基线资料、血清PCT及CRP、IL-6、SAA的表达水平。分析血清PCT及炎性因子CRP、IL-6、SAA在脓毒症患者中的诊断价值。结果两组研究对象的年龄、性别等基线资料差异无统计学意义。观察组患者的血清PCT、CRP、IL-6、SAA水平均明显高于对照组(P<0.05)。单独PCT与PCT联合CRP、IL-6、SAA对脓毒症的诊断价值差异无统计学意义,且均比传统炎性因子IL-6、CRP、SAA优秀。结论与传统炎性因子CRP、IL-6、SAA相比,血清PCT对脓毒症患者的诊断价值更加突出,值得推广。

OBJECTIVE To explore the application values of serum procalcitonin(PCT) and inflammatory factors C-reactive protein(CRP), interleukin-6(IL-6) and serum amyloid A(SAA) in early diagnosis of sepsis. METHODS Totally 42 patients with sepsis who were treated in department of critical care medicine from Jul 2016 to Oct 2017 were assigned as the observation group, the clinical data of the patients were analyzed, meanwhile, 46 healthy people who received physical examination were set as the control group. The baseline data and levels of serum PCT, CRP, IL-6 and SAA were compared between the two groups of patients;the values of serum PCT and inflammatory factors CRP, IL-6 and SAA in diagnosis of sepsis were observed. RESULTS There were no significant differences in the baseline data such as age and gender between the two groups of study objects. The levels of serum PCT, CRP, IL-6 and SAA of the observation group were significantly higher than those of the control group(P<0.05). There was no significant difference in the diagnostic value of sepsis between the single PCT and the joint detection of PCT, CRP, IL-6 and SAA, and the PCT was superior to the conventional inflammatory factors IL-6, CRP and SAA. CONCLUSION As compared with the conventional inflammatory factors CRP, IL-6 and SAA, the serum PCT had higher value in diagnosis of the patients with sepsis, and it is worthy to be promoted.