呼吸丙酮用于糖尿病监管的研究进展及临床应用前景

Breath acetone: trends in techniques and its potential clinical applications in diabetes management

人体呼出气体中含有数千种痕量挥发性有机化合物(VOCs),其中某些内源性物质可作为潜在的疾病生物标志物.丙酮作为人体呼出气体中含量第二高的VOCs,已被广泛用于糖尿病的无创诊断与监管研究.目前关于糖尿病患者呼吸丙酮浓度范围及其影响因素、其与血糖和糖化血红蛋白之间量化关系的独立研究已超过30项,然而呼吸丙酮能否作为糖尿病监管参数应用于临床还存在诸多挑战.综述了国内外呼吸丙酮分析的研究进展,讨论了呼吸丙酮在糖尿病诊断及监管方面的研究现状和存在的问题,并结合当前技术水平对未来发展前景进行了分析.

Human exhaled gases contain thousands of trace amounts of trace volatile organic compounds (VOCs),some of which are endogenous substance and can be detected as potential biomarkers for disease.Acetone,the second highest VOCs in human exhaled gases,has been widely used in non-invasive diagnosis and monitoring of diabetes.At present,more than 30 independent studies have been undertaken on the range of breath acetone concentration and its influencing factors,and the quantitative relationship between blood glucose and glycosylated hemoglobin in diabetic patients.However,there are still many challenges in the application of breath acetone as a clinical regulatory parameter for diabetes.In this paper,the research status and progress in the breath acetone and analysis method were reviewed,and the existing problems in diabetes diagnosis and monitoring were discussed.Besides,the future development prospects were analyzed with the present technical level.