一氧化氮与乳腺癌相关的细胞信号转导研究进展

Research progress in cellular signal transduction of nitric oxide and breast cancer

乳腺癌是女性最常见的恶性肿瘤之一,其发病率逐年上涨,是致使女性尤其是年轻女性死亡的最主要原因之一.研究影响乳腺癌发生和发展的相关细胞信号转导,有助于预防乳腺癌的发生,减缓癌症进展及改善患者预后.一氧化氮(NO)是一种信号分子,多项研究结果表明NO的生成和表达与乳腺癌密切相关,NO相关的细胞信号转导显著影响乳腺癌的发生和发展.然而,对NO与乳腺癌相关的细胞信号转导关系的认识有待进一步提高.对近年来关于乳腺癌中NO相关的细胞信号转导研究进行综述,以期提高对乳腺癌发生和发展的认识.

Breast cancer is one of the most common malignant tumors in women,and its incidence has increased year by year,which is one of the most important causes of death among women,especially young women.Studying related cell signal transduction that affects the development and progression of breast cancer can help prevent the occurrence of breast cancer,slow down the cancer progression and improve the prognosis of patients.nitric oxide (NO) is a kind of signaling molecule.Many studies have shown that the production and expression of NO are closely related to breast cancer.NO-related cell signal transduction significantly affects the occurrence and development of breast cancer.However,the understanding of the relationship between NO and breast cancer associated cell signal transduction needs to be further improved.In this paper,the related studies on NO-related cellular signal transduction in breast cancer were reviewed with a view to improving the understanding of the development and progression of breast cancer.