阿尔茨海默病生活方式危险因素Meta分析的再评价

Review of the Meta-analysis of lifestyle risk factors for Alzheimer disease

目的对影响阿尔茨海默病患病率的生活方式危险因素Meta分析进行再评价,以了解现有文献质量,同时为预防阿尔茨海默病提供依据。方法计算机检索CNKI、万方、CBM、PubMed、EMBASE、ProQuest、Cochrane Library数据库中的阿尔茨海默病生活方式危险因素Meta分析,并由2名研究者独立筛选文献、提取资料、使用JBI文献系统评价质量评价标准和Meta分析证据等级评价方法进行方法学和证据质量评价。结果最终纳入34篇文献,涉及的生活方式危险因素主要包括:吸烟、饮酒、运动、社会活动、睡眠、饮食、咖啡/茶,其中吸烟、饮酒、咖啡/茶的影响效果还需进一步证据支持。结论干预生活方式可预防阿尔茨海默病的发生,仍需开展更多高质量的原始研究探讨更多的阿尔茨海默病患病影响因素。

Objective To review the meta-analysis of lifestyle risk factors for Alzheimer disease in order to find out the quality of the current articles and to provide evidence for preventing Alzheimer disease. Methods CNKI, Wanfang, CBM, PubMed、EMBASE、ProQuest、Cochrane Library were searched on computer for Meta-analyses in lifestyle risk factors of Alzheimer disease. Two authors independently selected the articles, extracted data, and used JBI to evaluate the quality of literature system evaluation and the evaluation method of meta-analysis evidence grade for methodological and evidence quality evaluation. Results A total of 34 articles were included which involved smoking, alcohol consumption, exercise, social activities, sleep, diet, coffee/tea. Among them, the effects of smoking and drinking alcohol and coffee/tea need further support by evidence. Conclusions Intervention on lifestyle can be effective in preventing Alzheimer disease, however, more high quality original studies are needed to explore more risk factors of Alzheimer disease.