经颅磁刺激在帕金森病病理生理学研究及治疗中的应用

The application prospect of transcranial magnetic stimulation in the pathophysiology research and treatment of Parkinson′s disease

帕金森病是常见的神经系统退行性疾病,发病机制极其复杂,探明其潜在病理生理机制,寻找有效改善症状、修饰疾病及延缓进展的治疗手段,是目前亟待解决的重大问题。研究显示,经颅磁刺激具有广阔临床应用前景,未来可为探明帕金森病病理生理机制、挖掘诊疗新靶点提供新思路。同时其可能通过增强突触可塑性,保护单胺神经元,上调脑内单胺神经递质水平,最终调整功能紊乱的大脑网络而起到治疗帕金森病运动及非运动症状的作用。

Parkinson′s disease (PD) is a common neurodegenerative disease, pathogenesis of which is extremely complex.To explore the potential pathophysiological mechanism of PD and find effective treatment methods to improve symptoms, modify the disease and delay the progression are the major problems to be solved urgently. Studies have shown that transcranial magnetic stimulation (TMS) has a broad clinical application prospect, which might help clinicians to explore the pathophysiological mechanism of PD and provide new ideas for exploring new targets for diagnosis and treatment in the future. Meanwhile, TMS might play important roles in the treatment of PD motor and non-motor symptoms through enhancing synaptic plasticity, protecting monoamine neurons, increasing the monoamine neurotransmitter level in the brain, and adjusting the brain network with dysfunction.