帕金森病免疫炎症机制的研究进展

Research progress of immune-inflammatory mechanism in Parkinson′s disease

帕金森病(Parkinson′s disease)是一种常见的中枢神经系统变性疾病,发病机制目前尚不清楚。免疫炎性反应被认为是帕金森病发生及疾病进展的一个重要因素,其中包括小胶质细胞的过度激活、炎性细胞因子的升高、T淋巴细胞的组成和表型的变化、B淋巴细胞产生的抗体增加等。近年来研究者发现,帕金森病患者的T淋巴细胞可识别α-突触核蛋白的抗原表位,成为目前帕金森病发病机制的研究热点。我们就近年来固有免疫和适应性免疫炎性反应在帕金森病发病机制中的研究进展作一综述。

Pathogenesis of Parkinson′s disease (PD), a common neurodegenerative disease, is not well established. Immune-inflammatory responses are considered to be important in the development and progression of PD, including over-activated microglia, increased inflammatory cytokines, changes in compositions and phenotypes of T lymphocytes, increased antibodies produced by B lymphocytes. Recent studies have found that T cells in PD patients can recognize α-synuclein peptides and become a research hotspot. In this review, we summarize the research progress in innate and adaptive immune-inflammatory responses in pathogenesis of PD.