生物因子在牙骨质再生中的应用

Application of biological factor in cementum regeneration

牙骨质再生对牙周炎治疗中重建牙槽骨与牙的关系至关重要。目前牙周炎的主要治疗策略为刮治、翻瓣清创术等,但这些方法在牙骨质再生方面的作用有限。研究发现,很多生物因子包括釉基质衍生物、转化生长因子β、胰岛素样生长因子等均可促进牙骨质再生。另外,不同类型的牙骨质在重建牙骨质-牙周膜界面中发挥不同的作用。但目前在牙骨质再生研究中,尚缺乏对新生牙骨质的鉴别方法。本文将对影响牙骨质再生的生物因子和牙骨质的特异性分子标志物进行综述。

At the present day,curettage and periodontal surgery comprise the main strategy for the treatment of periodontitis,however,these methods are limited in regenerating cementum.It has been found that some biological factors such asenamel matrix derivative (EMD),transforming growth factor-β(TGF-β) and insulin-like growth factor (IGF) could promote cementum regeneration.In the cementum regenerationstudies,there has been a lack of criteria to distinguish cementum from alveolar bone and other types of cementum.Therefore,this article will briefly review the biological factors that affect the cementum regeneration and the molecular markers used to judge the regenerating cementum.