基于生物阻抗谱的人体细胞内外液容量计算方法研究

Study on calculation method of internal and external fluid capacity of human cells based on bioimpedance spectroscopy

生物电阻抗测量技术是一种无创的提取人体生理及病理信息的检测技术,其中对生物阻抗与人体生理参数之间关系的分析方法是该项技术环节中很重要的一部分。为了更加精准地计算人体细胞内外液容量,在计算人体细胞内外液容量的莫斯尔(Moissl)方程的基础上,本文提出了一种分段式人体生物阻抗谱测量模型及改进的细胞内外液容量计算方法,设计了人体摄入水分前后的细胞内外液容量的测量与计算实验,并与Moissl方程进行比较。结果表明,本文提出的改进计算方法能够更有效地计算细胞内外液容量,相对误差在5%以内,今后或可为人体成分的分析及疾病的诊断治疗提供新的思路或更为准确的方法。

Bioelectrical impedance measurement technology is a non-invasive detection technology for extracting human physiological and pathological information. The analysis method of the relationship between bioimpedance and human physiological parameters is an important part of this technology. In order to calculate the internal and external liquid volume of human cells more accurately, based on the Moissl equation for calculating the internal and external fluid volume of human cells, a segmented human bioimpedance spectrum measurement model and an improved calculation method of intracellular and external fluid capacity were proposed. The measurement and calculation experiments of the intracellular and extracellular fluid volume before and after the human body's water intake were designed and compared with the Moissl calculation method. The results show that the improved calculation method can calculate the intracellular and extracellular fluid volumes more effectively, and the relative error is less than 5%, which may provide new ideas or more accurate methods for the analysis of human body components, facilitating the diagnosis and treatment of diseases.