跑步机训练对老年阿尔茨海默病患者神经精神症状与生命质量的影响

Efficacy of treadmill training on neuropsychiatric symptoms and quality of life among elderly Alzheimer's disease

目的评价跑步机训练对老年阿尔茨海默病患者神经精神症状与生命质量的效果.方法选择2018年3-11月,于福建医科大学附属泉州第一医院康复科进行康复治疗的阿尔茨海默病患者为研究对象.采用随机对照试验,以随机分组软件进行随机分组,试验组和对照组各68例.试验组采取跑步机训练,对照组未采取任何干预.2组于训练前与训练20周后,采用神经精神症状问卷(NPI-Q)、阿尔茨海默病生命质量问卷(QOL-AD)进行效果评价,并以t检验、两因素重复测量方差分析等统计方法,进行数据分析.结果训练前2组患者的神经精神症状评分与QOL评分差异均无统计学意义(P>0.05).通过20周跑步机训练后,试验组阿尔茨海默病患者神经精神症状总分(训练前t=-1.317,P=0.204;训练20周后t=-10.01,P=0.046),情感症状(训练前t=-1.684,P=0.092;训练20周后(t=-11.26,P=0.043),精神病症状(训练前t=1.168,P=0.235;训练20周后t=-9.94, P=0.034),行为症状(训练前t=1.952,t=0.129;训练20周后t=-3.61,P=0.028),及QOL总分(训练前t=1.452,P=0.140;训练20周后t=22.27,P=0.040)均差异有统计学意义;试验组神经精神症状改善程度与对照组差异有统计学意义(F=23.10,P=0.000),而试验组QOL与对照组差异也有统计学意义(t=-8.88,P=0.000).结论以跑步机训练的非药物疗法,可改善老年阿尔茨海默病患者的神经精神症状,并提高生命质量.

Objective To analyze effect of Treadmill Training on neuropsychiatric symptoms and quality of life in elderly patients with Alzheimer′s disease. Methods From May 2018 to November 2018, the experimental design was adopted. The patients with 55-75 years old AD, the First Affiliated Hospital of Quanzhou Fujian Medical University were randomly divided into groups. Group (treadmill training, 68 patients), control group (no intervention, 68 patients). The two groups were evaluated before the training and 20 weeks after training, using the Neuropsychology Scale (NPI-Q) and the Alzheimer's disease Quality of Life Questionnaire (QOL-AD), and the t-test, two-factor repeated measures analysis of variance, etc. Statistical methods for data analysis. Results There were no significant differences in neuropsychiatric scores and QOL scores between the two groups before training (P>0.05). After training through a 20-week treadmill, the total score of neuropsychiatric symptoms in patients with Alzheimer's disease in the experimental group (t=-1.317, P=0.204 before training;t=-10.01, P=0.046 after 20 weeks of training), affective symptoms (Before training, t=-1.684, P=0.092;t=-11.26, P=0.043 after 20 weeks of training, psychiatric symptoms (t=1.168 before training, P=0.235;t=-9.94 after training for 20 weeks, P=0.034)), behavioral symptoms (t=1.952 before training, P=0.129;t=-3.61, P=0.028 after 20 weeks of training), and QOL total score (t=1.452, P=0.140 before training;t=22.27 after training, P=0.040) were statistically different;and the improvement of neuropsychiatric symptoms in the experimental group was significantly different from that in the control group (F=23.10, P=0.000), while the QOL of the experimental group was also significantly different from the control group (t=- 8.88, P=0.000). Conclusion Non-pharmacological treatment with treadmill training can improve neuropsychiatric symptoms and improve quality of life in elderly AD patients.