甘肃省2004-2018年丙型肝炎流行特征

Epidemiologic characteristics of hepatitis C in Gansu Province from 2004 to 2018

目的分析甘肃省丙型病毒性肝炎流行特征及其变化趋势,为制定防制措施提供科学依据。方法收集2004-2018年甘肃省丙型肝炎报告病例资料,采用Excel2010、SPSS19.0及ArcGIS10.5软件进行资料整理与统计分析。结果2004-2018年甘肃省累计报告丙型肝炎病例数为102802例,其中死亡42例,报告发病率从2004年的12.39/10万上升到2018年的33.92/10万(χ^2=9849.90,P<0.001)。报告发病率随着年龄的增长呈上升趋势(χ^2=26784.53,P<0.001),≥80岁年龄组报告发病率最高(94.09/10万),≥50岁年龄组报告发病率均超过50.00/10万。报告病例中农民所占比例逐年上升,2018年农民所占的构成比达67.31%。14个市(自治州)报告发病率均呈增长趋势,累计报告发病率排在前三位的市(自治州)是武威市(1098.42/10万),张掖市(1077.69/10万)和兰州市(692.55/10万)。结论甘肃省丙肝报告疫情仍呈上升趋势,应加强重点人群和地区疫情监测,加强健康教育,提高公众对丙肝的认识。

Objective The aim is to provide scientific evidence for the strategy of prevention and control through analyzing the epidemic characteristics and change tendency of hepatitis C virus infection in Gansu Province.Methods Data of hepatitis C virus infection reported cases in Gansu Province from 2004 to 2018 were collected and analyzed by Excel 2010,SPSS 19.0 and ArcGIS 10.5 software.Results 102 802 hepatitis cases were reported including 42 death cases in Gansu Province from 2004 to 2018. The reported incidence increased from 12.39 per 100 000 in 2004 to 33.92 per 100 000 in 2018 (χ^2 = 9 849.90,P < 0.001).The reported incidence of hepatitis C virus infection showed a rising trends with the aging of the patients (χ^2 = 26 784.53,P < 0.001),and the highest reported incidence was the group of over 80 years( 94.09 per 100 000),and exceed 50.00 per 100 000 from the each group of over 50 years.Moreover,the proportion of farmers of the reported cases increased year by year and the proportion of farmers was 67.31% in 2018.The reported incidence rates of 14 cities ( autonomous prefecture) in Gansu Province showed an increasing trend.The cities ( autonomous prefecture) with the highest reported incidence rates were Wuwei ( 1 098.42 per 100 000),Zhangye ( 1 077.69 per 100 000) and Lanzhou City ( 692.55 per 100 000).Conclusions The epidemic situation of hepatitis C virus infection in Gansu Province is still rising.It is necessary to strengthen the surveillance of key populations and areas,enhance health education,and raise public awareness of hepatitis C virus infection.