组氨酸磷酸酶LHPP对胰腺癌预后的影响

The expression of protein histidine phosphatase LHPP is associated with prognosis in patients with pancreatic cancer

目的观察组氨酸磷酸酶LHPP的表达对胰腺癌预后的影响.方法收集99例胰腺癌术后患者癌组织及癌旁组织病理切片,应用组织芯片免疫组织化学技术检测癌组织及癌旁组织中LHPP表达水平,收集患者的临床病理特征,统计LHPP的表达水平与胰腺癌术后患者临床病理特征及预后的关系.应用x2检验比较癌组织与癌旁组织LHPP表达强度是否有差异,分析胰腺癌患者的临床病理因素与LHPP表达高低的相关性.用Kaplan-Meier法和Log-rank法行生存时间分析.使用Graphpad prism 6.0软件绘制生存曲线.结果 LHPP在胰腺癌组织中表达水平低于癌旁组织(x2=19.841,P<0.05),其表达与病理分级(x2=6.386,P<0.05)、美国癌症分期委员会(AJCC)分期(x2=4.608,P<0.05)和短期死亡(x2=6.832,P<0.01)相关.LHPP表达水平与胰腺癌患者预后相关(x2=11.342,P<0.05),表达越高生存期越长.LHPP表达(P<0.05)、病理分级(P<0.01)和N分期(P<0.01)为影响胰腺癌患者预后的独立影响因素.结论 LHPP表达是胰腺癌预后的独立危险因素,高表达者预后较好.

Objective To study the effect of the expression of protein histidine phosphatase LHPP on the prognosis of pancreatic cancer. Methods Pathological sections of cancer tissues and adjacent non-tumor tissues from 99 patients with pancreatic cancer after operations were collected. Tissue microarray-based immunohistochemistry technique was used to detect the expression of LHPP in pancreatic cancer tissues. Clinicopathological features of the patients were collected, and the relationship between the expression of LHPP and the clinicopathological features of pancreatic cancer was analyzed. Results The expression of LHPP in pancreatic cancer tissue was lower than that in adjacent non-tumor tissue (χ2=19.841, P<0.05). The expression of LHPP was related to histological grade (χ2=6.386, P<0.05), American Joint Committee on Cancer (AJCC) stage (χ2=4.608, P<0.05) and whether dead in short time (χ2=6.832, P<0.01). The expression of LHPP was related to the overall survival rate of pancreatic cancer patients (χ2=11.342, P<0.05). The higher the expression of LHPP, the longer the survival time. The expression of LHPP (P<0.05), histological grade (P<0.01), and N stage (P<0.01) were independent factors influencing the prognosis of pancreatic cancer patients. Conclusion The expression of LHPP is an independent prognostic factor for pancreatic cancer. The prognosis of high expression group is better than that of low expression group.