酪氨酸激酶/信号转导转录激活因子3与神经性疼痛的研究进展

Progress in research on janus kinase/signal transducer and activator of transcription3 and neuropathic pain

神经性疼痛是一种由躯体感觉系统损伤或疾病引起的疼痛.在一般人群中神经性疼痛的患病率为6.9%~ 10.0%,其严重困扰着患者的生活质量,给个人、家庭、社会带来极大负担.许多因素均可导致神经性疼痛,包括损伤或先天性疾病等.因此,探究神经病理性疼痛治疗的分子靶点具有重要意义.近年来学者们通过调控长链非编码核糖核酸(lncRNA)、研究中药成分等方式探索靶向治疗神经性疼痛的新途径.酪氨酸激酶/信号转导转录激活因子3(JAK/STAT3)通路作为参与神经性疼痛重要组成之一,但目前诸多机制尚不明确.本文通过阐述JAK/STAT3与神经性疼痛的新进展作一综述.

Neuropathic pain is caused by somatosensory system injury or disease. The prevalence of neuropathic pain in the general population is about 6.9%-10.0% which produces bad effects to quality of life of patients and imposes great burden on individuals, families and society. Many factors could lead to neuropathic pain, such as injuries and congenital diseases. Therefore, exploring the molecular targets of neuropathic pain treatment is of great significance. In recent years, scholars have explored new ways about targeted therapy of neuropathic pain by regulating long non-coding RNA (lncRNA) and studying the composition of traditional Chinese medicine. The janus kinase (JAK)/signal transducer and activators of transcription 3 (STAT3) pathway is one of the important components that involved in neuropathic pain, but specific mechanism is still unclear. This article reviews the recent advances in JAK/STAT3 and neuropathic pain.