摘要
长链非编码RNA(Long non-coding RNA,Lnc RNA)是序列长度大于200个核苷酸且不翻译成蛋白质的功能性RNA分子。LncRNA在恶性肿瘤的临床应用中有重大价值,与肿瘤的诊断、预防、治疗及预后有密切联系。人类结肠癌相关转移因子-1(Colon cancer associated transcript-1 CCAT1)可以通过促进细胞增殖、侵袭和迁移来发挥致癌作用,CCAT1可以作为肿瘤预后的生物标志物。本文就近年来人们对于CCAT1与消化系统恶性肿瘤关系的研究进展做一综述,并探讨通过CCAT1治疗恶性肿瘤的现状和前景。
Long non-coding RNAs(lncRNAs)is a functional RNA molecule with a sequence length greater than 200 nucleotides that is not translated into a protein.LncRNA is of great value in the clinical application of malignant tumors and is closely related to the diagnosis,prevention,treatment and prognosis of tumors.CCAT1(human colon cancer associated transcript-1)can play a carcinogenic role by promoting cell proliferation,invasion and migration.CCAT1 can be used as a biomarker for tumor prognosis.In this review,the research progress on the relationship between CCAT1 and digestive system malignant tumors is reviewed in recent years,the current status and prospects of malignant tumor treatment by CCAT1 are discussed.
作者
赵金璐
李国东
刘明
ZHAO Jinlu;LI Guodong;LIU Ming(The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《实用肿瘤学杂志》
CAS
2019年第4期367-370,共4页
Practical Oncology Journal
基金
哈尔滨医科大学创新基金项目(编号:2017LCZX116)
