胃癌免疫检查点抑制剂作用机制及最新研究进展

Mechanism and recent progress of gastric cancer in immunological checkpoint inhibitors

胃癌治疗方法有限,预后较差。目前肿瘤免疫治疗因其显著的生存获益已成为除手术、化疗、放疗及靶向治疗之外有效的新型肿瘤治疗手段。免疫检查点抑制剂作为肿瘤免疫治疗的方法之一,已被批准用于多种肿瘤的治疗,提示胃癌免疫治疗时代已经到来。本文介绍了免疫治疗中免疫检查点抑制剂的作用机制及相关研究进展。

The treatment of gastric cancer is limited and the prognosis is poor.Tumor immunotherapy has been an effective new treatment for cancer in addition to surgery,chemotherapy,radiotherapy and targeted therapy because of its remarkable survival benefit.As one of the methods of tumor immunotherapy,immunological checkpoint inhibitors have been approved for the treatment of various tumors,suggesting that the era of gastric cancer immunotherapy has arrived.This article describes the mechanism of action and related research progress of immunological checkpoint inhibitors in immunotherapy.