N-苯氧基乙酰胺导向的碳氢键官能团化反应研究进展

Recent Advances in N-Phenoxyacetamides Directed C—H Bond Functionalizations

碳氢键活化反应因具有原子经济性和步骤简捷性的特点,近年来成为有机化学研究的热点领域之一.在传统的碳氢键活化反应中,通常需要加入等物质的量的氧化剂来实现催化剂的再生,使催化循环顺利地发生.而N-苯氧基乙酰胺作为一种新型的含有氧化型导向基的反应底物,可以有效地避免等物质的量外加氧化剂的使用,使碳氢键活化在氧化还原中性的条件下进行.综述了N-苯氧基乙酰胺在有机合成领域特别是碳氢键活化反应中的最新研究进展,并对反应的机理进行了讨论.

The C-H bond activation has become one of the hot fields of organic chemistry in recent years due to its atom economy and step simplicity.In the conventional C-H bond activations,an equivalent amount of oxidants is usually added to regenerate the catalyst and allow the catalytic cycle proceed smoothly.N-Phenoxyacetamide,as a novel reaction substrate containing an oxidizing directing group,can effectively avoid the use of an equivalent external oxidants.Thus,the C-H activation could be conducted under redox neutral conditions.In this paper,the latest research progress of N-phenoxyacetamides in the field of organic synthesis,especially C-H bond activations is reviewed,and the mechanism of the reaction is discussed.