3D打印技术在有机合成化学中的应用

Application of 3D Printing Technology in Organic Synthetic Chemistry

相对于传统的材料去除-切削加工技术,3D打印作为一种“自下而上”的材料累加制造方法,不仅操作简单、制造成本更低以及可实现快速生成,而且可实现复杂结构件的精确定制.因此,3D打印已成为第三次工业革命的代表性技术.近年来,化学家们将3D打印技术与有机合成相结合,在多通道异相催化剂和新型反应装置的研发设计等方面取得了积极的进展,进而使这项技术在有机合成领域中应用越来越广泛.对近年来基于3D打印技术的有机合成研究进展进行了综述,涵盖基于3D打印异相催化剂或催化剂载体、3D打印反应装置和3D打印流反应器,并对该领域的发展趋势进行了展望.

Compared with traditional material removal-cutting method,3D printing is a"bottom-up"material accumulation manufacturing technology.This novel technology is not only simple to operate,but also has a lower manufacturing cost and can be quickly generated.What's more,3D printing technology can fabricate the be-spoke objects with intricate internal structures.Therefore,3D printing has been a representative technology of the third industrial revolution.In recent years,chemists have combined 3D printing technology with organic synthesis and made many good achievements in the development of new multichannel heterogeneous catalysts and reaction devices,which has made this technology more and more widely used in the field of organic synthesis.In this review,the progress of the organic synthesis based on 3D printing technology from 2012 to 2018 are summarized,such as 3D-printed heterogeneous catalysts,3D-printed devices and 3D-printed continuous flow microreactors.Furthermore,the development trends of this field in the future are also prospected.