胸腔镜肺叶切除术治疗非小细胞肺癌的效果分析

Effect analysis of thoracoscopic lobectomy in the treatment of non-small cell lung cancer

目的探讨胸腔镜肺叶切除术治疗非小细胞肺癌的效果.方法40例非小细胞肺癌患者,随机分为观察组(21例)及对照组(19例).观察组给予胸腔镜肺叶切除术治疗,对照组给予开胸手术治疗.对比两组患者的手术相关指标[术中出血量、住院时间、术后疼痛数字评分法(NRS)评分、术后胸腔引流时间、淋巴结切除个数]、手术前后肺功能指标[最大通气量(MVV)、第1秒用力呼气容积(FEV1)]及并发症发生情况.结果观察组患者的术中出血量、住院时间、术后NRS评分、术后胸腔引流时间分别为(140.21±32.22)ml、(8.01±2.00)d、(4.01±0.35)分、(4.65±1.11)d,均优于对照组的(301.01±35.61)ml、(11.20±2.41)d、(5.26±0.71)分、(6.15±1.36)d,差异均有统计学意义(P<0.05).两组患者的淋巴结切除个数对比,差异无统计学意义(P>0.05).术前,两组患者的FEV1、MVV对比,差异均无统计学意义(P>0.05);术后1个月,观察组患者的FEV1、MVV分别为(1.70±0.23)L、(65.07±1.42)%,均高于对照组的(1.52±0.19)L、(60.32±1.33)%,差异均具有统计学意义(P<0.05).观察组患者的并发症发生率为4.76%,与对照组的15.79%对比,差异无统计学意义(P>0.05).结论非小细胞肺癌应用胸腔镜肺叶切除术治疗能有效提高治疗效果,控制并发症的发生.

Objective To discuss the effect of thoracoscopic lobectomy in the treatment of non-small cell lung cancer. Methods A total of 40 patients with non-small cell lung cancer were randomly divided into observation group(21 cases) and control group(19 cases). The observation group was treated with thoracoscopic lobectomy, and the control group was treated with open thoracotomy. Comparison was made on surgical related indicators [amount of intraoperative hemorrhage, hospitalization time, postoperative numerical rating scale(NRS)score, postoperative thoracic drainage time and number of lymph node dissection], pulmonary function index[maximum ventilation volume(MVV), forced expiratory volume in the first second(FEV1)] before and after operation and occurrence of complications between the two groups. Results The observation group had better amount of intraoperative hemorrhage, hospitalization time, postoperative NRS score and postoperative thoracic drainage time respectively as(140.21±32.22) ml,(8.01±2.00) d,(4.01±0.35) points and(4.65±1.11) d than(301.01±35.61) ml,(11.20±2.41) d,(5.26±0.71) points and(6.15±1.36) d in the control group. Their difference was statistically significant(P<0.05). There was no statistically significant difference in number of lymph node dissection between the two groups(P>0.05). Before operation, there was no statistically significant difference in and FEV1 and MVV between the two groups(P>0.05). At 1 month after operation, the observation group had higher FEV1 and MVV respectively as(1.70±0.23) L and(65.07±1.42)% than(1.52±0.19) L and(60.32±1.33)% in the control group. Their difference was statistically significant(P<0.05). The observation group had no statistically significant difference in incidence of complications as 4.76%, compared with 15.79% in the control group(P>0.05). Conclusion Thoracoscopic lobectomy can improve the treatment of non-small cell lung cancer and control the occurrence of complications.