中药干预缺血性脑卒中血脑屏障序贯性破坏的研究进展

Study Progress on Traditional Chinese Medicine Intervention for Sequential Destruction of Blood-Brain Barrier in Ischemic Stroke

血脑屏障是脑与血液循环之间的重要物理屏障,对维持脑内相对平衡的微环境和中枢神经信号的有效传递发挥着关键的作用。缺血性脑卒中发生后,最新研究发现血脑屏障存在着序贯性损伤的特性,早期主要以升高的胞吞转运为主,后期主要表现在紧密链接蛋白的解离与重塑。中药对生理和病理状态下的血脑屏障通透性都具有调节作用,在阐述缺血性脑卒中血脑屏障序贯性破坏的病理演变基础上,系统整理和归纳了中药对中风后血脑屏障的保护作用机制,探讨了中药降低血脑屏障序贯性损伤的可行性,为今后开辟新的中风治疗路径提供理论基础。

The blood-brain barrier is an important physical barrier between the blood circulation and brain, which plays a key role in maintaining the relative balance of the microenvironment and the effective transmission of central nervous signals. The latest study suggests that the blood-brain barrier is sequential injury after ischemia. The early phase is mainly the elevation of endocytic transport, and the anaphasis mostly because of the dissociation and remodeling of tight-junctions. Traditional Chinese medicine has a regulating effect on the permeability of blood-brain barrier under physiological and pathological conditions. This article focuses on expounding the pathological evolution of the sequential destruction of blood-brain barrier in ischemic stroke, systematically summarizing the protection mechanism of the traditional Chinese medicine on the blood-brain barrier after stroke. The protective mechanism of the brain barrier explores the feasibility of traditional Chinese medicine to reduce the sequential damage of the blood-brain barrier, and provides theoretical basis for new treatment of stroke in the future.