扶正解毒汤联合GP化疗治疗中晚期非小细胞肺癌临床观察

Clinical Observation of Fuzheng Jiedu Decoction Combined with GP Chemotherapy in Reatment of Advanced Non-Small Cell Lung Cancer

目的:探讨扶正解毒汤联合GP化疗治疗中晚期非小细胞肺癌的临床效果。方法:选择78例非小细胞肺癌患者作为研究对象,按照随机数字的方法分为对照组和观察组,每组39例患者,对照组使用GP方案进行化疗,观察组在对照组治疗方法基础上给予扶正解毒汤,对两组完成3个月治疗之后的治疗效果、不良发生的情况和生活质量进行对比,对两组的无疾病进展生存时间和总生存时间进行比较。结果:完成3个月治疗后,观察组的治疗效果,治疗有效率均优于对照组,数据差异具有统计学意义(z=-1.180,χ^2=4.154,P<0.05),两组的疾病控制率数据差异不具有统计学意义(χ^2=2.372,P>0.05),观察组白细胞计数减少和血红蛋白减少的发生率低于对照组,数据差异具有统计学意义(χ^2=4.514,4.514,P<0.05),其余项目的数据差异均不具有统计学意义(χ^2=0.181,0.264,0.855,0.289,0.181,0.052,0.000,0.264,P>0.05),观察组生活质量变化程度优于对照组,数据差异具有统计学意义(z=-3.168,P<0.05),对照组的无进展生存时间中位数为7.985个月,观察组的无进展生存时间中位数为11.973个月,数据差异具有统计学意义(χ^2=5.475,P<0.05),对照组的总生存时间中位数为11.229个月,观察组的总生存时间中位数为12.722个月,数据差异具有统计学意义(χ^2=5.305,P<0.05)。结论:利用扶正解毒汤联合GP化疗治疗中晚期非小细胞肺癌患者,可以提升治疗效果,延长生存时间,安全性良好。

Objective:To explore the clinical effect of Fuzheng Jiedu Decoction combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer. Methods:Seventy-eight patients with non-small cell lung cancer were selected as subjects. According to the method of random number, they were divided into control group and observation group, and each group had 39 patients. The patients in the control group were treated with GP regimen, and the patients in the observation group were given Fuzheng Jiedu Decoction on the basis of the treatment method of the control group. The treatment outcomes, adverse events and quality of life of the two groups after 3 months treatment were compared. We compared disease-free survival time and overall survival time between the two groups of patients. Results:After 3 months treatment, the treatment effect of the observation group patients was better than that of the control group. The data was statistically significant(z=-1.180,χ^2=4.154, P<0.05). There was no statistically significant difference in disease control rate data between the two groups(χ^2=2.372, P>0.05). The incidence of white blood cell count reduction and hemoglobin reduction in the observation group were lower than those in the control group, and the data was statistically significant(χ^2=4.514, 4.514, P<0.05). The data differences of the other items were not statistically significant(χ^2=0.181, 0.264, 0.855, 0.289, 0.181, 0.052, 0.000, 0.264,P>0.05). The quality of life of the observation group was better than that of the control group, and the data was statistically significant(z=-3.168, P<0.05). The median progression-free survival time was 7.985 months in the control group and 11.973 months in the observation group. The data was statistically significant(χ^2=5.475, P<0.05). The median overall survival time of the control group was 11.229 months. The median survival time of the observation group was 12.722 months. The difference was statistically significant(χ^2=5.305,P<0.05). Conclusion:The use of Fuzheng Jiedu Decoction combined with GP chemotherapy in the treatment of patients with advanced non-small cell lung cancer can improve the therapeutic effect, prolong the survival time and has good safety.