安宫牛黄丸对重症脑出血认知功能、NF-κB水平影响分析

Effect of Angong Niuhuang Pill on Level of NF-κB in Patients with Severe Cerebral Hemorrhage

目的:分析安宫牛黄丸对重症脑出血患者认知功能、核因子-κB(NF-κB)水平影响。方法:选取82例重症脑出血患者的临床资料进行分析,根据治疗方法不同分为对照组(常规治疗)和观察组(常规治疗+安宫牛黄丸治疗),分析两组患者治疗后的临床效果。结果:治疗7、14 d后,观察组脑血肿体积小于对照组,但组间比较不具有统计学意义(P>0.05)。治疗7、14 d后,观察组患者血管内皮生长因子(VEGF)、超氧化物歧化酶(SOD)水平高于对照组,NF-κB、丙二醛(MDA)水平低于对照组,格拉斯哥昏迷(GCS)评分、简易精神状态检查量表(MMSE)评分高于对照组(P<0.05)。治疗7 d时,观察组患者美国国立卫生院卒中量表(NIHSS)评分低于对照组,但治疗14 d时,观察组患者NIHSS评分与对照组比较,不具有统计学意义(P>0.05)。观察组患者不良反应率低于对照组(χ^2=9.612;P=0.002)。结论:安宫牛黄丸治疗重症脑出血可改善患者认知功能和神经功能,且安全性高,其机制可能与调节NF-κB、MDA、VEGF、SOD水平有关。

Objective:To analyze the effect of Angong Nihuang Pill on cognitive function and nuclear factor-κB(NF-κB) level in patients with severe cerebral hemorrhage.Methods:The clinical data of 82 patients with severe intracerebral hemorrhage(ICH) was analyzed. According to the treatment methods, they were divided into control group(conventional treatment) and observation group(routine treatment of Angong Niuhuang Pills). We analyzed the clinical effect of two groups after treatment.Results:After 7 and 14 days treatment, the volume of cerebral hematoma in the observation group was smaller than that in the control group, but there was no significant difference between the two groups(P>0.05). After 7 and 14 days treatment, the levels of vascular endothelial growth factor(VEGF), superoxide dismutase(SOD), NF-κB and malondialdehyde(MDA) in the observation group were higher than those in the control group, and the Glasgow coma(GCS) score was lower than that in the control group. The MMSE score of simple mental state examination scale was higher than that of the control group(P<0.05). After 7 days treatment, the NIHSS score of stroke scale in the observation group was lower than that in the control group, but 14 days after treatment, the NIHSS score of the observation group was not significantly different from that of the control group(P>0.05). The adverse reaction rate in the observation group was lower than that in the control group(χ^2=9.612,P=0.002). Conclusion:Angong niuhuang Pills can improve patients’ cognitive function and nerve function in the treatment of severe cerebral hemorrhage, and it has high safety. Its mechanism may be related to the regulation of nf-astringb, MDA, VEGF and SOD levels.