玉屏风颗粒联合匹多莫德对变应性鼻炎合并支气管哮喘的临床疗效探究

Curative Efficacy of Yupingfeng Granules Combined with Pidomodin in Treatment of Allergic Rhinitis with Bronchial Asthma

目的:探讨玉屏风颗粒联合匹多莫德对变应性鼻炎合并支气管哮喘患儿的临床疗效。方法:选择变应性鼻炎合并支气管哮喘患儿80例作为研究对象,以随机数表法分为观察组(n=43)和对照组(n=37),对照组使用匹多莫德治疗,观察组在对照组的基础上使用玉屏风颗粒进行治疗。比较两组的临床疗效、嗽消失时间、喘息消失时间、肺部啰音消失时间、治疗前后肺功能、治疗前后哮喘症状评分、变应性鼻炎症状评分及不良反应发生情况。结果:治疗后,观察组临床疗效总有效率为93.02%,明显比对照组的72.97%高(P<0.05);治疗后,观察组患儿咳嗽消失时间、喘息消失时间、肺部啰音消失时间均显著低于对照组(P<0.05);治疗前,两组患者肺功能水平无显著差异(P>0.05);治疗后,两组各肺功能指标较治疗前均显著升高(P<0.05),观察组FEV1、PEF水平均明显高于对照组(P<0.05);治疗前,两组患者哮喘症状评分、变应性鼻炎症状评分无显著差异(P>0.05);治疗后,两组哮喘症状评分、变应性鼻炎症状评分较治疗前均显著下降(P<0.05),观察组哮喘症状评分、变应性鼻炎症状评分均明显低于对照组(P<0.05);观察组不良反应总发生率为4.65%,显著低于对照组的29.73%(P<0.05)。结论:在变应性鼻炎合并支气管哮喘患儿中使用玉屏风颗粒联合匹多莫德效果显著,可有效改善患儿的临床症状,值得推广与运用。

Objective:To study the curative efficacy ofYupingfeng Granules combined with pidomodin in the treatment of allergic rhinitis with bronchial asthma.Methods:Eighty cases of allergic rhinitis combined with bronchial asthma treated in our hospital from March 2016 to March 2018 were selected as study objects. According to the random number table method,the patients were divided into observation group(n=43) and control group(n=37). The control group was treated with pidemodeand the observation group was treated with YupingfengGranules on the basis of the control group. The clinical efficacy, the dying time of mouthwash, wheezing time, lung rumbling time, lung function before and after treatment, asthma symptom score before and after treatment, allergic rhinitis symptom score and adverse reactions were compared between the two groups.Results:After treatment, the total effective rate in the observation group was 93.02%, significantly higher than 72.97% in the control group(P<0.05). After treatment, the duration of cough disappeared, wheezing disappeared and lung rumble disappeared in the observation group were significantly lower than those of the control group(P<0.05). Before treatment, there was no significant difference in pulmonary function between the two groups(P>0.05). After treatment, lung function indexes in both groups were significantly higher than those before treatment(P<0.05), and FEV1 and PEF levels in the observation group were significantly higher than those in the control group(P<0.05). Before treatment, there was no significant difference in asthma symptom score or allergic rhinitis symptom score between the two groups(P>0.05). After treatment, the asthma symptom score and allergic rhinitis symptom score of the two groups were significantly lower than those of the two groups before treatment(P<0.05). The asthma symptom score and allergic rhinitis symptom score of the observation group were significantly lower than those of the control group(P<0.05). The total incidence of adverse reactions was 4.65% in the observation group, significantly lower than 29.73% in the control group(P<0.05). Conclusion:The use of YupingfengGranules in combination with pidomode in children with allergic rhinitis and bronchial asthma has significant effects, which can effectively improve the clinical symptoms of children and is worthy of promotion and application.