中药熏洗联合普通针刺对肛肠患者术后创面愈合影响及机制分析

Effect of Traditional Chinese Medicine Fumigation and Washing Combined with Common Acupuncture on Postoperative Wound Healing in Anorectal Patients

目的:探讨中药熏洗联合普通针刺对肛肠患者术后创面愈合的影响及其机制分析。方法:选择2016年1月—2017年12月在本院行肛肠手术的154例患者作为研究对象,根据随机数字表法将154例患者分为观察组(77例)和对照组(77例),术后对照组患者予以高锰酸钾溶液坐浴治疗,观察组患者予以中药熏洗联合普通针刺治疗,对比分析两组患者的症状改善时间、临床疗效,同时釆用酶联免疫法检测治疗前后两组患者血清中神经肽SP含量。结果:观察组患者的术后便血消失时间、肛缘水肿消失时间、疼痛消失时间、伤口愈合时间均明显短于对照组,均P<0.05。治疗前,观察组及对照组患者的肛门坠胀评分及肛门疼痛评分比较,差异无统计学意义,均P>0.05。治疗后,观察组及对照组患者的肛门坠胀评分及肛门疼痛评分均明显低于治疗前,且观察组明显低于对照组,均P<0.05。观察组总有效率为98.70%,对照组总有效率为81.82%,观察组的总有效率明显高于对照组,P<0.05。治疗前,观察组及对照组患者的神经肽SP含量比较,差异无统计学意义,P>0.05。治疗后,观察组及对照组患者的神经肽SP含量均明显高于治疗前,且观察组明显高于对照组,P<0.05。结论:在肛肠术后患者中施以中药熏洗联合普通针刺治疗,可有效促进术后创面的愈合,其作用机制可能与上调创面神经肽SP的表达有关。

Objective:To investigate the effect of traditional Chinese medicine fumigation and washing combined with common acupuncture on postoperative wound healing in anorectal patients and its mechanism analysis.Methods:154 patients who underwent anorectal surgery in our hospital from January 2016 to December 2017 were selected as subjects.According to the random number table method,154 patients were divided into observation group(77 cases)and control group(77 cases),the patients in the control group were treated with potassium permanganate solution,and the patients in the observation group were treated with traditional Chinese medicine fumigation and washing combined with ordinary acupuncture.The symptom improvement time and clinical efficacy of the two groups were compared.To detect neuropeptide SP content in the two groups before and after treatment by ELISA.Results:The disappearance time of postoperative blood in the stool,the disappearance time of anal edema,the time of pain disappearance,and the time of wound healing were significantly shorter in the observation group than in the control group,all with P<0.05.Before treatment,the anal swell score and anal pain scores of the observation group and the control group were not statistically significant,all with P>0.05.After treatment,the anus bulge score and anal pain score of the observation group and the control group were significantly lower than before treatment,and the observation group was significantly lower than the control group,both P<0.05.The total effective rate of the observation group was 98.70%,and the total effective rate of the control group was 81.82%.The total effective rate of the observation group was significantly higher than that of the control group,P<0.05.Before treatment,there was no significant difference in neuropeptide SP content between the observation group and the control group,P>0.05.After treatment,the levels of neuropeptide SP in the observation group and the control group were significantly higher than those before treatment,and the observation group was significantly higher than the control group,P<0.05.Conclusion:The application of traditional Chinese medicine fumigation and washing combined with ordinary acupuncture in patients with anorectal surgery can effectively promote the healing of postoperative wounds.The mechanism may be related to the up-regulation of the expression of neuropeptide SP.