参附注射液对脓毒症病人急性肾损伤的效果

Effect of Shenfu injection on acute renal injury induced by sepsis

目的:分析参附注射液对脓毒症病人急性肾损伤及其他脏器损伤的治疗效果。方法:将72例脓毒症病人随机分成对照组和观察组各36例,对照组病人按照指南给予标准治疗,观察组病人在标准治疗的基础上添加参附注射液。比较2组病人治疗前后血清肌酐、血尿素氮、胱抑素C水平的变化情况、其他脏器损伤以及死亡情况。结果:治疗前2组病人血清肌酐、血尿素氮、胱抑素C水平差异均无统计学意义(P>0.05),治疗后均比治疗前明显降低(P<0.01),且观察组明显低于对照组(P<0.01);治疗前2组病人丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、乳酸脱氢酶、肌酸激酶及脑钠肽水平差异均无统计学意义(P>0.05),治疗后水平均明显降低(P<0.01),且观察组低于对照组(P<0.01);观察组病人的死亡率(2.8%)明显低于对照组(22.2%)(P<0.05),且生存时间也长于对照组(P<0.05)。结论:参附注射液可有效减轻脓毒症病人急性肾损伤及其他脏器损伤,降低死亡率。

Objective: To investigate the therapeutic effects of Shenfu injection in the acute renal injury and other organs injury induced by sepsis. Methods: Seventy-two patients with sepsis were randomly divided into the control group and observation group(36 cases each group).The control group was treated with routine method,and the observation group was treated with Shenfu injection combined with conventional method.The changes of the serum levels of creatinine,blood urea nitrogen and cystatin C in two groups between before and after treatment,and other organ damage and death between two groups were compared. Results: The differences of the levels of serum creatinine,blood urea nitrogen and cystatin C between two groups before treatment were not statistically significant ( P > 0.05),which were significantly higher than those after treatment,and the levels of serum creatinine,blood urea nitrogen and cystatin C in observation group after treatment were significantly lower than those in control group( P <0.01).The differences the levels of serum alanine aminotransferase,aspartate aminotransferase,lactate dehydrogenase,creatine kinase and brain natriuretic peptide between two groups before treatment were not statistically significant( P >0.05),which in two groups significantly decreased after treatment,and the levels of serum alanine aminotransferase,aspartate aminotransferase,lactate dehydrogenase,creatine kinase and brain natriuretic peptide in observation group were lower than those in control group( P <0.01).The death rate in observation group(2.8%) was significantly lower than that in control group(22.2%)( P <0.05),and the survival time in observation group was longer than that in control group( P <0.05). Conclusions: Shenfu injection can effectively alleviate the acute kidney injury and other organs injury,and reduce the mortality in sepsis patients.