轻度高尿酸血症与肾小球滤过率及尿白蛋白肌酐比的相关研究

Correlations of mild hyperuricemia with GFR and ACR

目的:探讨我国南方社区人群中无症状轻度高尿酸血症(hyperuricemia,HUA)与预估肾小球滤过率(estimated GFR,eGFR)及尿白蛋白肌酐比(albumin-creatinine ratio,ACR)的关系,分析轻度HUA对肾脏的不利影响。方法:对广东省珠海市 1 276 名社区居民行横断面调查,在全人群及男、女性人群中分别比较轻度HUA组与正常组eGFR、ACR的差异。使用单因素、多因素及逐步logistic回归模型探讨轻度HUA是否构成eGFR降低及ACR轻度升高的危险因素。结果:在全人群及女性人群中,轻度HUA组eGFR均低于正常组,且单因素、多因素及逐步logistic回归模型均显示轻度HUA是eGFR降低的危险因素;在全人群、男性及女性人群中,轻度HUA组ACR与正常组的组间差异均无统计学意义( P >0.05);在全人群中,仅单因素logistic回归模型显示轻度HUA构成ACR轻度升高的危险因素。结论:无症状轻度HUA可能对南方社区人群特别是女性人群的肾脏滤过功能产生不利影响。

Objective: To investigate the association between asymptomatic mild hyperuricemia(HUA) and estimated glomerular filtration rate(eGFR),urinary albumin-creatinine ratio(ACR) among community population in South China,and analyze the adverse effects of mild hyperuricemia on kidney. Methods: A cross-sectional study was conducted among 1 276 community residents in Zhuhai Guangdong province.The differences of eGFR and ACR in male,female and the whole population between mild hyperuricemia group and normal group were compared.Whether the mild hyperuricemia leading to the eGFR decreasing and mild ACR increasing or not was explored using the univariate,multivariate and stepwise logistic regression models. Results: Among the female and whole population,the eGFR in mild hyperuricemia group was lower than that in normal group,and the results of univariate,multivariate and stepwise logistic regression models analysis showed that the mild hyperuricemia was a risk factor of the eGFR decreasing.The differences of ACR mild between mild hyperuricemia group and normal group among the male,female and whole population were not statistically significant( P > 0.05 ).Among whole population,the results of univariate logistic regression model analysis showed the mild hyperuricemia was a risk factor of mild ACR increasing. Conclusions: The asymptomatic mild hyperuricemia may have an adverse effect on the glomerular filtration function of the community population,especially the female population in South China.