胎盘病理炎性改变与新生儿细菌感染指标的相关性研究

Study on the correlation between placental pathology and bacterial infection indicators in neonates

目的探讨胎盘病理炎性改变与新生儿细菌感染指标的相关性。方法选取2016年12月至2017年12月在该院妇产科出生、疑有新生儿感染并于24h内转入该院新生儿科住院治疗的新生儿共62例作为研究对象,其中23例胎盘经病理学检查提示存在胎盘病理炎性改变者为观察组,39例胎盘病理无炎性改变者为对照组,所有纳入研究的新生儿进入新生儿科后进行白细胞(WBC)、C-反应蛋白(CRP)、降钙素原(PCT)等细菌感染指标的动态监测,分析胎盘病理炎性改变与新生儿细菌感染指标的相关性。结果观察组新生儿细菌感染发生率明显高于对照组(78.2%vs.35.9%),差异有统计学意义(P<0.05);观察组血WBC、CRP(24~96h)与PCT(72~96h)水平较对照组明显升高,差异有统计学意义(P<0.05);胎膜早破及早产是发生胎盘病理炎性改变的高危因素(P<0.05)。结论胎盘炎性改变是导致新生儿细菌感染的主要原因之一;胎盘病理炎性改变与新生儿细菌感染指标具有相关性。

Objective To investigate the correlation between pathological inflammatory changes of placenta and bacterial infection in neonates.Methods A total of 62 neonates who were born in the Department of Obstetrics and Gynecology,and suspected of neonatal infection and transferred to the Department of Neonatology in this hospital within 24 hours from December 2016 to December 2017 were selected as the study subjects.Among them,23 cases of neonates showed pathological inflammatory changes in placenta were selected as the observation group,39 cases of neonates without inflammatory changes in placenta were taken as the control group.After admission,all newborns were dynamic monitored for bacterial infection indicators such as white blood cell(WBC),C-reactive protein(CRP),procalcitonin(PCT)and to analyze the correlation between pathological inflammatory changes of placenta and neonatal bacterial infection indicators.Results The incidence of neonatal bacterial infection in the observation group was significantly higher than that in the control group(P<0.05).The levels of WBC,CRP(24th to 96th hour)and PCT(72th to 96th hour)in the observation group were significantly higher than those in the control group(P<0.05).The two factors of premature rupture of membranes and premature delivery were high risk factors for pathological inflammatory changes of placental(P<0.05).Conclusion Pathdogical inflammatory change of placenta is one of the main causes of bacterial infection in neonates.Pathdogical inflammatory changes of placenta were correlated with neonatal bacterial infection indicators.