干细胞治疗子宫内膜损伤及促进生育的研究进展

Research advances in stem cell therapy for endometrial injury and fertility promotion

子宫内膜损伤是由诸如宫腔内有创操作、感染等多种因素引起的子宫内膜变薄、内膜基底层损伤,从而造成子宫内膜再生和修复障碍,临床上以月经量过少、闭经、不孕等为主要表现,严重困扰患者。轻中度的子宫内膜损伤可通过宫腔镜下宫腔粘连(IUA)分离术、大剂量雌激素等常用的临床治疗方法得到一定改善。然而重度的子宫内膜损伤至今仍缺乏有效而成熟的治疗方法。干细胞可促进子宫内膜再生和修复,改善内膜功能,本文就干细胞治疗子宫内膜损伤和提高患者妊娠率方面的研究进展及未来展望做简要综述。

Endometrial injury is a kind of endometrial thinning and endometrial basal layer damage caused by various factors such as intrauterine invasive operation and infection,resulting in endometrial regeneration and repair disorders.Clinically,menstruation,amenorrhea,infertility are the main manifestations of endometrial injury,which seriously plague patients.Mild endometrial injury can be improved by hysteroscopic adhesions separation,high dose estrogen and other common clinical treatment methods.However,severe endometrial injury still lacks effective and mature treatment methods.Stem cells can promote the regeneration and repair of endometrium and improve the function of endometrium.This article reviewed the research progress and future prospects of stem cells in the treatment of endometrial injury and the improvement of pregnancy rate.