四川地区健康人群快速血栓弹力图参考区间的建立

Establishment of rapid-thrombelastography reference interval for healthy population in sichuan

目的测定四川地区健康人群快速血栓弹力图(r-TEG)数据,确立符合该地区特点的正常值参考范围,并与试剂厂家提供的正常值进行比较。方法收录2017年8-10月在四川大学华西医院体检的健康成年人群,进行r-TEG检测,并对凝血反应时间(ACT和R)、凝血形成时间(K)、凝固角(Angle)、最大振幅(MA)、纤维蛋白溶解率(LY30和EPL)等参数进行分析。结果共纳入153名成人体检健康者,使用r-TEG方法分析得出各参数正常参考值分别为ACT:89~121s,R:25~45s,K:50~155s,Angle:64~81deg,MA:51~71mm,LY30:0~3.7,EPL:0~3.7。9.2%(14/153)的健康成人至少1项参数超出厂家提供的正常范围。男女性别间分组比较,男性参考范围:ACT:89~126s,R:25~48s,K:50~171s,Angle:59~81deg,MA:47~70mm,LY30:0~3.7;EPL:0~3.7,女性参考范围:ACT:89~121s,R:25~45s,K:50~111s,Angle:70~81deg,MA:55~71mm,LY30:0~4.3,EPL:0~4.3,除了LY30和EPL外,其余各项参数间的差异均具有统计学意义(P<0.01)。结论实验室有必要建立符合本地区人群特点的r-TEG正常参考范围。

Objective To determine the data of rapid-thromboelastography(r-TEG)of healthy people in Sichuan,and to establish the reference range of normal values which conform to the characteristics of the region,and to compare with the normal values provided by reagent manufacturers.Methods Healthy adults who underwent physical examination in West China Hospital of Sichuan University from August to October 2017 were enrolled in this study,the r-TEG was detected.The coagulation reaction time(ACT,R),coagulation formation time(K),coagulation angle(Angle),maximum amplitude(MA),fibrinolysis rate(LY30 and EPL)and other parameters were analyzed.Results A total of 153 healthy adults were enrolled.The normal reference values of each parameter were ACT:89-121 s,R:25-45 s,K:50-155 s,Angle:64-81 deg,MA:51-71 mm,LY30:0-3.7 and EPL:0-3.7,respectively.9.2%(14/153)of healthy adults had at least one parameter beyond the normal range provided by the manufacturer.For comparison between male and female groups,male reference ranges:ACT:89-126 s,R:25-48 s,K:50-171 s,Angle:59-81 deg,K:50-171 s,K:50-171 s,Angle:59-81 deg,MA:47-70 mm,LY30:0-3.7,EPL:0-3.7,EPL:0-3.7,female reference ranges:ACT:89-121 s,R:25-45 s,K:25-45 s,K:50-111 s,Angle:70-81 deg,Angle:70-81 deg,MA:55-71 mm,LY55-71 mm,LY30:0-4.3,EPL:0-4.3,except for LY30 and EPL,there were significant differences in other parameters(P<0.05).Conclusion It is necessary for laboratories to establish a normal reference range of r-TEG in accordance with the characteristics of the local population.