葡萄籽提取物原花青素对2型糖尿病人群血糖、血脂影响的干预研究

Intervention study on that effect of grape seed extract proanthocyanidins on blood glucose and blood lipid in the patients with type 2 diabetes mellitus

目的研究葡萄籽提取物原花青素(GSPE)对2型糖尿病患者血糖、血脂等相关指标的影响,并探讨相关作用机制。方法将新诊断且3个月内未接受注射胰岛素及服用降糖药等糖尿病相关治疗的2型糖尿病患者34例纳入研究,采用随机双盲的方式分为GSPE组和对照组,各17例。GSPE组给予口服GSPE干预,对照组给予口服安慰剂,在干预前和连续干预12周后,测定患者糖化血红蛋白(HbA1c)、空腹胰岛素水平(FINS)、空腹血糖(FBG)水平、餐后2小时血糖(PBG)及总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的水平,同步计算评价胰岛素耐受的体内稳态模型(HOMA-IR)指数并同步监测患者肝功能、肾功能及血常规指标变化情况。结果连续干预12周后,GSPE组的FBG、HbA1c、FINS、HOMA-IR指数、TC和LDL-C水平较干预前明显降低,干预前后的水平变化与对照组比较差异有统计学差异(P<0.05)。干预前后GSPE组患者的肝功能、肾功能及血常规指标水平变化与对照组比较差异均无统计学意义(P>0.05)。结论GSPE对2型糖尿病患者有明显的降低血糖和改善血脂的作用,有利于改善糖尿病症状,且机体无肝功能、肾功能及造血功能相关的不良反应,其作用机制可能与其能抗氧化应激能力、缓解血清胰岛素抵抗水平、修复损伤的β细胞、调节β胞的增殖和凋亡、抑制LDL-C氧化修饰、调节糖脂代谢作用有关。

Objective To study the effect of grape seed extract procyanidins on blood sugar,blood lipid and other related indicators in type 2 diabetes mellitus patients,and to explore the related mechanism.Methods Thirty-four patients with type 2 diabetes who were newly diagnosed and did not receive insulin injection or hypoglycemic drugs within 3 months were selected as the study subjects.They were randomly divided into grape seed extract procyanidins group(GSPE group)and control group in a double-blind manner,with 17 cases in each group.The grape seed extract procyanidins group was given oral intervention with grape seed extract procyanidins,and the control group was given oral placebo.Before and after 12 weeks of continuous intervention,the levels of glycosylated hemoglobin(HbA1c),fasting insulin(FINS),fasting blood glucose(FBG),2-hour postprandial blood glucose(PBG),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)were measured.The HOMA-IR index was calculated and the changes of liver function,renal function and blood routine indexes were monitored simultaneously.Results After 12 weeks of continuous intervention,the levels of FBG,HbA1c,FINS,HOMA-IR index,TC and LDL-C in the GSPE group were significantly lower than those before the intervention,The level changes before and after intervention were significantly different from those of the control group(P<0.05).There were no statistically significant changes in liver function,renal function and blood routine indicators in the GSPE group compared with the control group(P>0.05).Conclusion Grape seed extract procyanide has the effect of reducing blood sugar and improving blood fat for type 2 diabetics,which is good for diabetes,and the adverse reactions associated with the body without liver function,kidney function,and the function of the function of the function,it may be associated with the ability to resist oxidative stress,to reduce serum insulin resistance,to repair the damage of beta cells,to regulate the proliferation and apoptosis of the beta cells,to suppress the effects of LDL-C,to regulate the metabolism of sugar fat.