摘要
放射性的间碘苄胍在临床上被广泛用于神经内分泌瘤的诊断和治疗。相比于有载体方法合成的[*I]MIBG,无载体方法合成的[*I]MIBG已经被证实了更有效且副作用更小。现合成了一种无载体MIBG的锡前体——间位三丁基锡基苄胍,经试验标记率为85%以上。
Radioiodinated meta-iodobenzylguanidine ([*I]MIBG) is used extensively in clinic for various neuroendocrinal diagnosis and therapy.No-carrier-added [*I]MIBG has been proved to be more effective and have fewer side effects compared with carrier-added [*I]MIBG.Here we synthesized a tin precursor from commercially available starting material from which [*I]MIBG can be easily made in a no-carrier-added way with the radiochemical yield over 85%.
作者
陈志明
王刚
汪洋
吴二明
黄荷云
CHEN Zhiming;WANG Gang;WANG Yang;WU Erming;HUANG Heyun(NHC Key Laboratory of Nuclear Medicine,Jiangsu Key Laboratory of Molecular Nuclear Medicine,Jiangsu Institute of Nuclear Medicine,Wuxi,Jiangsu,214063)
出处
《药学与临床研究》
2019年第4期246-248,共3页
Pharmaceutical and Clinical Research
关键词
间碘苄胍
锡前体
无载体
MIBG
Tin precursor
No-carrier-added
