CD151及CD163在乳腺癌组织中的表达及其临床意义

The expression and the clinical significance of CD151 and CD163 in breast cancer

目的:研究乳腺癌组织中CD151与CD163的表达水平同时分析两个指标与乳腺癌临床病理参数及预后的关系。方法:使用免疫组化检测100例乳腺癌和30例正常乳腺组织中CD151及CD163(M2巨噬细胞标记物)的表达水平,使用SPSS统计学软件分别对CD151和CD163与乳腺癌的临床病理参数之间的关系和两者的相关性进行统计学分析。结果:CD151表达在乳腺癌细胞的胞膜及胞质,CD163表达在乳腺癌组织的间质,CD151与CD163的阳性表达率分别为70%(70/100)和67%(67/100),与正常乳腺组织相比,差异具有统计学意义(P<0.001)。CD151的阳性表达与乳腺癌组织学分级、TNM分期、淋巴结转移、ER(-)、PR(-)、Her-2(+)显著相关(P<0.05),CD163的阳性表达与肿瘤体积、乳腺癌组织学分级、TNM分期、淋巴结转移、ER(-)、PR(-)、Her-2(+)显著相关(P<0.05),乳腺癌组织中CD151与CD163的表达呈正相关(r=0.701,P<0.001),CD151与CD163双阳性乳腺癌患者具有更高的复发转移率(P<0.05)。结论:乳腺癌组织中CD151与CD163表达明显增高,并与不良的乳腺癌行为密切相关。因此,乳腺癌组织中CD151与CD163表达高低对判断乳腺癌的预后具有重要作用。

Objective:To study the expression of CD151 and CD163 in breast cancer tissues and to analyze the relationship between the two indexes and the clinicopathological parameters and prognosis in breast cancer.Methods:The expression of CD151 and CD163(M2 macrophages marker) in 100 breast cancer and 30 normal breast tissues were detected by immunohistochemical assay.The correlation of CD151 and CD163 and the clinicopathological parameters in breast cancers were statistically analyzed using SPSS statistical software.Results:CD151 was expressed in the membrane and cytoplasm of breast cancer cells rather than interstitial(within tissues) like CD163.The expressions of CD151 and CD163 in breast cancer were respectively 70%(70/100) and 67%(67/100),showing statistical differences compared to normal breast tissue(P<0.001).The positive expression of CD151 was significantly correlation with poor grading,TNM staging,lymph node metastasis,ER negative,PR negative,and Her-2 positive(P<0.05) in breast cancer.The positive expression of CD163 was significant correlation with large tumor size,poor grading,TNM staging,lymph node metastasis,ER negative,PR negative,and Her-2 positive in breast cancer(P<0.05).The expression of CD151 was positively correlated to CD163 in breast cancer(r=0.701,P<0.001).The recurrence and metastasis rate in breast cancer patients with CD151 and CD163 positive were significantly higher than the other group(P<0.05).Conclusion:The expression of CD151 and CD163 were significantly up-regulated in breast cancer tissues,which was closely related to the poor behavior of breast cancer.Therefore,the expression of CD151 and CD163 in breast cancer tissues were important in judging the prognosis of breast cancer.