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HPV-1妇科抑菌凝胶曦曦爱抗HPV感染的临床有效性评价 被引量:2

Clinical evaluation of xixiai which was a HPV-1 gynecological antibacterial gel for anti-HPV infection
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摘要 目的采用曦曦爱HPV卵黄抗体妇科抑菌凝胶(Immunoglobulin of yolk,IgY)治疗妇科HPV感染患者,观察其治疗结果,总结临床数据,验证其临床有效性。方法选取山东济南市立五院门诊和荣成市人民医院健康管理中心于2017年10月~2018年8月收治的HPV染患者120例,分为重组人干扰素a-2b凝胶治疗组(60例)和曦曦爱治疗组(60例)。重组人干扰素a-2b凝胶组、曦曦爱治疗组按照产品推荐使用方案对纳入患者进行治疗干预,治疗前后采用21种HPV分型检测试剂盒(PCR+膜杂交法)进行检测,判定HPVDNA定量变化情况。临床试验结束后统计临床数据。结果单一HPV感染为82例,两型HPV感染者28例,三重感者10例。与治疗前相比,两种治疗方式的HPVDNA核酸定量明显降低,且曦曦爱治疗组相对于重组人干扰素a-2b凝胶组下降更为显著(P<0.0001)。曦曦爱治疗组的有效率明显高于干扰素治疗组(P=0.00001)。结论曦曦爱HPV-1妇科抑菌凝胶(卵黄抗体)对彻底清除特定HPV病毒一过性感染、持续性感染、单一和混合亚型感染效果优于重组人干扰素a-2b凝胶治疗,且临床过程中未见明显不良反应,因此可用于HPV感染的预防和治疗。 Objective Treat HPV-infected patients with gynecological HPV gynecological antibacterial gel whichwasnamedxixiai,observe the treatment results,summarize the clinical data,and verify its clinical effectiveness.Methods 120 patients with cervicitis and HPV infection admitted to a gynecology department in two hospitals in Shandong province from October2017 to August 2018 were selected.Divided into recombinant human interferon a-2b gel treatment group(60 cases)and xixiai treatment group(60 cases).Recombinant human interferon a-2b gel group and xixiai treatment group were treated with therapeutic intervention according to the recommended product regimen,Before and after treatment,21 types of HPV typing test kits(PCR+membrane hybridization)were used for detection to determine the quantitative changes of HPV DNA.Statistical data were collected after the clinical trial.Result There were 82 cases of single HPV infection,28 cases of two types of HPV infection and 10 cases of triple sensitivity.The quantitative amount of HPV DNA in the two treatments was significantly lower than that nontreatment.Compared with recombinant human interferon a-2b gel group,the decline in the xixiai treatment group was more significant(P<0.0001),and the effective rate of the xixi love treatment group was significantly higher than that of the interferon treatment group(P=0.00001).Conclusion xixiai is superior to recombinant human interferon a-2b gel in the complete elimination of specific HPV virus transient infection,persistent infection,single and mixed subtype infection.And there was no obvious adverse reactions in the clinical process,so it can be used for the prevention and treatment of gynecological inflammation caused by HPV infection.
作者 多晓玲 侯春丽 董凯 殷民 Dou Xiao-ling;Hou Chun-li;Dong Kai;Yin Min(Department of Obstetrics and Gynecology, Jinan Fifth People's Hospital, Shandong Jinan 250022,china;Department of Anatomy, Military Medical University, Chongqing Key Laboratory of Biomechanics and Tissue Engineering,Chongqing 400038,China;Rongcheng People's Hospital,Shandong Rongcheng 264300,china;Department of Oncology, Jinan Fifth People's Hospital,Shandong Jinan 250022,China)
出处 《实用妇科内分泌电子杂志》 2019年第20期2-3,15,共3页 Electronic Journal of Practical Gynecological Endocrinology
关键词 曦曦爱HPV-1妇科抑菌凝胶 卵黄抗体 妇科 HPV 临床有效性 评价 Xixiai HPV-1 gynecological bacteriostatic gel Egg antibody Gynecology HPV Clinical
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