纤溶酶治疗下肢深静脉血栓的疗效及对下肢深静脉血流动力学的影响

Effect of Plasmin on Deep Venous Thrombosis and its Effect on Venous Blood Flow Mechanics of Lower Extremity

目的:探讨纤溶酶治疗下肢深静脉血栓(DVT)的疗效及对患者下肢深静脉血流动力学的影响。方法:前瞻性的选取2017年6月至2018年2月我院住院部收治的184例DVT患者作为研究对象,数字随机法分成两组,每组92例,对照组为常规治疗,观察组为纤溶酶治疗;观察两组患者临床疗效,并比较两组患者治疗前后血流动力学和炎症反应。结果:临床疗效上,观察组有效率为92.39%,显著高于对照组的81.52%(χ^2=4.792,P<0.05)。在血流动力学中,治疗前两组患者纤维蛋白原(FIB)、血浆粘度(PV)、全血高切粘度(HSV)、全血低切粘度(LSV)均无显著差异(P>0.05);治疗后组间比较,观察组患者FIB、HSV、LSV均显著低于对照组(t=2.984、3.039、2.197,P<0.05)。在炎症因子中,治疗前两组患者C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)均无显著差异(P>0.05);治疗后组间比较,观察组患者CRP、TNF-α、IL-6均显著低于对照组(t=9.999、6.580、8.536,P<0.05)。结论:对DVT患者应用纤溶酶治疗,能够提高临床疗效,显著改善血流动力学,并清除炎症因子。

Objective: To investigate the effect of plasmin on DVT and its effect on deep venous blood flow mechanics of lower limbs. Methods: Prospective selection of 184 DVT patients from June 2017 to February 2018 as subjects in our hospital. Divided into two groups according to the numerical random table method, 92 cases in each group. The control group was treated as a normal treatment, and the observation group was treated for plasmin. To observe the clinical efficacy of two patients. And compare the two groups before and after treatment in patients with hemodynamics and inflammatory reaction. Results: In clinical efficacy, the effective rate of the observation group was 92.39%, which was significantly higher than that of the control group (81.52%)(χ^2= 4.792, P<0.05). There were no significant differences in FIB, PV, HSV and LSV between the two groups before treatment (P>0.05). After treatment, the FIB, HSV and LSV in the observation group were significantly lower than those in the control group (t=2.984,3.039,2.197,P<0.05). There were no significant differences in CRP, TNF- and il-6 between the two groups before treatment (P>0.05). After treatment, CRP, TNF-a and IL-6 in the observation group were significantly lower than those in the control group (t=9.999, 6.580, 8.536, P<0.05). Conclusion: Fibrinolytic therapy for DVT patients can improve clinical efficacy, significantly improve hemodynamics, and eliminate inflammatory factors.