米力农联合多巴胺对慢性心力衰竭的疗效及对血清CysC NT-proBNP IL-6的影响

Curative Efficacy of Milrinone Combined with Dopaminein Treatment of Chronic Heart Failure and Effects on CysC NT-proBNP IL-6 Levels

目的:探讨米力农联合多巴胺对慢性心力衰竭的疗效及对胱抑素C(CysC)、N-末端B型利钠肽前体(NT-proBNP)、白介素-6(IL-6)的影响.方法:选择2017年6月至2018年9月我院接诊的65例慢性心力衰竭患者作为本研究对象,通过简单随机数表法分为观察组35例和对照组30例,对照组给予常规治疗,观察组在对照组基础上,不给予洋地黄制剂,给予米力农联合多巴胺治疗,均连续治疗7d.比较两组临床疗效、心功能、血清CysC、NT-proBNP、IL-6的变化及不良反应.结果:治疗后,观察组临床疗效总有效率明显高于对照组(P<0.05);两组左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)、血清CysC、NT-proBNP、IL-6在组间·不同时间点具有交互作用(P<0.05);两组治疗期间均未出现肝肾功能异常、血尿常规异常等不良反应,观察组有1例室性前收缩.结论:米力农联合多巴胺用于慢性心力衰竭患者短期治疗效果显著,可有效降低血清CysC、NT-proBNP、IL-6的表达,改善心功能,临床应用价值高.

Objective: To study the curative efficacy of milrinone combined with dopaminein treatment of chronic heart failure and effects on Cystatin C(CysC), N-terminal B type natriuretic peptide precursor(NT-proBNP), interleukin-6(IL-6) levels. Methods: 65 patients of chronic heart failure who received therapy from June 2017 to September 2018 in our hospital were selected as research objects, they were divided into observation group (35 cases) and control group (30 cases) by simple random number table method. The control group was given routine treatment, while the observation group was given milrinone combined with dopamine without digitalis preparation, they were continuous treatment for 7d. The clinical efficacy, the changes of serum CysC, NT-proBNP, IL-6 and adverse reactions were compared between the two groups. Results:: After treatment, the total effective rate in the observation group was significantly higher than those in the control group(P<0.05);there were significant differences in the interaction of left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), serum CysC, NT-proBNP and IL-6 between groups at interblock·different time points(P<0.05);there were no adverse reactions such as abnormal liver and kidney function, abnormal blood and urine routine, and 1 case of ventricular premature contraction in the observation group. Conclusion:: Milrinone combined with dopaminein is well for chronic heart failure, which can effectively reduce the expression of serum CysC, NT-proBNP and IL-6, the clinical application value is high.