调节性T细胞参与ANCA相关血管炎的发病机制

Role of regulatory T cells in pathogenesis of ANCA-associated vasculitides

调节性T细胞(Tregs)是维持外周免疫耐受必需的重要细胞,是阻止自身免疫的关键T细胞亚群,当免疫调节功能异常时造成T细胞的持续活化,从而导致抗中性粒细胞胞浆抗体相关血管炎(AAV)的发生发展,本文就AAV中Tregs分子表型、作用机制以及调节功能异常的可能潜在原因等相关方面作一阐述。

Regulatory T cells (Tregs) are important cells for maintaining peripheral immune tolerance, which are key T cell subsets that prevent autoimmunity.When immune regulation is abnormal, T cells are continuously activated, resulting in ANCA-associated vasculitides.In this review, we will discuss the current knowledge on the role of Tregs and phenotype and mechanism of action in the AAV pathogenesis and how aberrations in their immune regulatory properties might contribute to disease progression.