甲状腺微小髓样癌8例临床病理分析

Thyroid micromedullary carcinoma: clinicopathologic study of 8 cases

目的探讨甲状腺微小髓样癌的临床病理特征、诊断及治疗。方法收集8例甲状腺微小髓样癌,分析其临床病理学特征并复习相关文献。结果甲状腺微小髓样癌病灶小,癌细胞起源于甲状腺滤泡旁C细胞,间质丰富,癌细胞具有多形性,核仁不清晰,核分裂象较少见,被纤维血管和(或)淀粉样物分隔。免疫组化标记Calcitonin(+)可作为诊断指标。结论甲状腺微小髓样癌的术后组织病理检查是明确诊断的金标准,甲状腺全切术配合中央区及侧区淋巴结清扫是当前患者的最优治疗方案。

Purpose To investigate the characteristics,pathological features,diagnosis and treatment of thyroid micromedullary carcinoma.Methods Eight cases of thyroid micromedullary carcinoma were collected.The pathological and diagnostic features were analyzed.Results The focus of thyroid micromedullary carcinoma were small.The cancer cells originated from the parafollicular C cells.The interstitial cells were abundant,the cancer cells were pleomorphic,the nucleolus was not clear,the nuclear mitosis was rare,separated by fibrovascular and/or amyloid stroma.Immunohistochemical marker of Calcitonin(+)could be used as a diagnostic marker.Conclusion The postoperative histopathological examnintaion of thyroid micromedullary carcinoma is the gold standard for its definite diagnosis.Total thyroidectomy with central and lateral lymph node dissection is the best treatment for the patients.