胺碘酮与普罗帕酮治疗心律失常临床疗效及安全性的对比分析

Comparative Analysis of Clinical Efficacy and Safety of Amiodarone and Propafenone in the Treatment of Arrhythmia

目的探究胺碘酮与普罗帕酮治疗心律失常临床疗效及安全性。方法入选该次研究中的100例研究对象为该院于2017年2月-2018年5月期间收治的室上性和室性患者心律失常患者,100例患者依据随机数值表方法平均划分为观察和对照两组,每组患者入选50例。对照组患者治疗药物选择普罗帕酮,观察组患者治疗药物选择胺碘酮,待两组患者经过治疗后比较其临床疗效和安全性。结果(1)观察组治疗总有效率为94%,对照组治疗总有效率为80%,两组数据经对比差异有统计学意义(P<0.05);(2)观察组和对照组患者治疗前sDNNindex(74.1±8.4)vs(74.5±8.6),SDNN(84.1±8.6)vs(85.5±8.7)和rMSSD(16.0±10.1)vs(16.1±10.6)(t=0.235 2、0.8092、0.048 2,P>0.05);两组患者治疗后sDNNindex(95.1±9.2)vs(80.3±8.2),SDNN(117.7±8.1)vs(92.1±7.8)和rMSSD(30.1±4.6)vs(20.2±4.8)经统计对比,差异有统计学意义(t=8.491 7、16.097 7、10.529 5,P<0.05);(3)观察组不良反应发生率为4%,对照组不良反应发生率为20%,两组数据经比较差异有统计学意义(P<0.05)。结论心律失常患者采用胺碘酮实施治疗效果显著,和普罗帕酮相比较药物优势存在,用药具有安全可靠性。

Objective To investigate the clinical efficacy and safety of amiodarone and propafenone in the treatment of arrhythmia.Methods One hundred subjects enrolled in this study were patients with supraventricular and ventricular arrhythmias admitted to our hospital between February 2017 and May 2018.100 patients were divided into observation group and control group ac.cording to the random number table method,with 50 patients in each group.In the control group,propafenone was selected as the treatment drug,and the patients in the observation group were treated with amiodarone.The clinical efficacy and safety of the two groups were compared after treatment.Results 1.The total effective rate of the observation group was 94%,and the total effective rate of the control group was 80%.The difference between the two groups was statistically significant(P<0.05);2.the observation group and the control group before treat ment sDNNindex(74.1±8.4)vs(74.5±8.6),SDNN(84.1±8.6)vs(85.5±8.7)and rMSSD(16.0±10.1),(16.1±10.6)(t=0.235 2,0.809 2,0.048 2,P>0.05);statistical comparison between sDNNindex(95.1±9.2)vs(80.3±8.2),SDNN(117.7±8.1)vs(92.1±7.8)and rMSSD(30.1±4.6),(20.2±4.8)after treatment(t=8.491 7,16.097 7,10.529 5,P<0.05);3.the incidence of adverse reactions in the observation group was 4%,and the incidence of adverse reactions in the control group was20%.The data of the two groups were compared by the difference was statistically significant(P<0.05).Conclusion Patients with arrhythmia treated with amiodarone have significant therapeutic effects.Compared with propafenone,the drug has advantages,safe and reliable.