宫颈癌根治调强放疗的复发模式及影响因素

Recurrence pattern and influencing factors of intensity-modulated radiotherapy for cervical cancer

随着精确放疗技术的快速发展,调强适形放疗(IMRT)在妇科恶性肿瘤中的应用也越来越广泛。IMRT具有较好的局部控制率,用于宫颈癌根治性放疗有着良好的临床结局。放疗的复发模式包括野内复发、野外复发及野内野外同时复发,宫颈癌根治性IMRT的复发模式主要为放射野外复发,野外复发可能与治疗前影像学评估不足有关,野内复发可能与靶区内放射剂量不足、肿瘤敏感性差异有关。

With the rapid development of precise radiotherapy technology, the use of intensity-modulated radiation therapy (IMRT) in gynecological malignant tumor has been gradually increased. IMRT could result in a good local control rate as well as superior clinical outcome in patients with cervical cancer after radical radiotherapy. The recurrence pattern of radiotherapy includes in-field recurrence, out-of-field and combined failure. The recurrence pattern of radical IMRT for cervical cancer is mainly out-of-field recurrence. Out-of-field recurrence may be related to inadequate imaging evaluation before treatment. In-field recurrence may be related to insufficient radiation dose in target area and differences of tumor sensitivity.