单纯乳腺癌与乳腺癌合并甲状腺癌患者临床病理特征分析

Analysis of clinicopathological features of patients with simple breast cancer and breast cancer with thyroid cancer

目的探讨乳腺癌与甲状腺癌发病的相关性。方法收集747例Ⅰ~Ⅲ期女性浸润性乳腺癌患者的临床病理资料,比较单纯乳腺癌组(723例)与乳腺癌合并甲状腺癌组(24例)的差异,分析乳腺癌患者发生甲状腺癌的影响因素。结果单纯乳腺癌组和乳腺癌合并甲状腺癌组患者的月经状态、ER状态差异有统计学意义(均P<0.05),乳腺癌合并甲状腺癌组中绝经前患者的比例(75.0%)和ER阳性患者的比例(83.3%)高。多因素Logistic回归分析显示,患者的月经状态(相对于绝经前患者,围绝经期患者OR=0.53,95% CI为0.07~4.25;绝经后患者OR=0.23,95% CI为0.08~0.65)和BMI(OR=1.14,95% CI为1.02~1.28)是乳腺癌合并甲状腺癌的独立影响因素。结论甲状腺癌与乳腺癌发病有关,肥胖及绝经前乳腺癌患者更容易合并甲状腺癌。

Objective To investigate the relationship between breast cancer and thyroid cancer. Methods A cohort of 747 female patients with stage Ⅰ-Ⅲ invasive breast cancer were enrolled in this retrospective study.The differences of clinical and pathological data were compared between the simple breast cancer group (723 cases) and the breast cancer with thyroid cancer group ( 24 cases), to analyze the relevant factors of second primary thyroid cancer in patients with breast cancer. Results There were significant differences in the menstrual status and estrogen receptor ( ER) status between the group of patients with breast cancer only and breast cancer patients with secondary primary thyroid cancer (P<0.05). Breast cancer patients with secondary primary thyroid cancer were more likely to be premenopausal (75%) and ER?positive (83.3%). Multivariate logistic regression analysis showed that the patient′s menstrual status (compared with premenopausal patients, peri-menopausal odds ratio=0.53, 95% CI 0.07-4.25;post?menopausal odds ration=0.23, 95%CI 0.08-0.65) and body mass index ( BMI, odds ratio=1.14, 95%CI 1.02-1.28) were independent risk factors for secondary primary thyroid cancer in patients with breast cancer. Conclusion Thyroid cancer is associated with breast cancer, and is more likely to occur in obesity patients and premenopausal patients.