肥胖与复发性流产的相关性研究进展

Research progress on the correlation between obesity and recurrent pregnancy loss

肥胖是一种全身性代谢疾病,近年来其发病率逐年上升。复发性流产是危害育龄期夫妇身心健康的妊娠并发症,病因复杂。本文从染色体异常、免疫失衡、蜕膜化受损、内分泌紊乱、血栓前状态、表观遗传学6个方面探讨肥胖和复发性流产的相关性,以期为肥胖及其相关因素导致的复发性流产提供治疗思路。

Obesity is a systemic metabolic disease. The incidence of obesity has increased year by year. Recurrent pregnant loss (RPL) is a pregnancy complication which endangers the physical and mental health of couples of reproductive age. The etiology of RPL is complicated. This article discusses the correlation of obesity and RPL on several aspects, including chromosomal abnormality, immune imbalance, impaired decidualization, endocrine disorder, prethrombotic state, and epigenetics, to provide treatment ideas for RPL caused by obesity and its related factors.