抗单纯疱疹病毒活性的海洋化合物研究进展

Research advances in marine compounds with anti-herpes simplex virus activity

单纯疱疹病毒是全球高度流行的病原体。目前核苷类药物如阿昔洛韦被用于单纯疱疹病毒的治疗,但是存在许多缺陷,如生物利用度低、溶解度小等副作用,尽管有些具有安全性和有效性,但长期使用会导致耐药病毒株的出现。海洋物质具有作用范围广、不易产生耐药性等特点,使人们对海洋生物如藻类、海绵、被囊类动物、棘皮动物、软体动物、细菌以及真菌等作为抗HSV药物的来源产生了极大的兴趣。本综述重点介绍和总结了作为潜在抗HSV药物最有希望的海洋生物提取物、组分等,以期为新型抗HSV药物的研发提供参考。

Herpes simplex virus(HSV)is a highly prevalent pathogen in the world.The current treatments for HSV infections are nucleoside analogs such as acyclovir.Despite the safety and efficacy,extensive clinical use of these drugs has led to the emergence of resistant viral strains,especially in immunocompromised patients.To counteract these problems,alternative anti-HSV agents from marine derived natural products have been reported.Recently,there has been a great deal of interest regarding marine organisms such as algae,sponges,tunicates,echinoderms,mollusks,shrimp,bacteria,and fungus as promising anti-HSV agents.This review highlights and summarizes the most promising marine biological extracts and components as potential anti-HSV drugs,so as to provide reference for the development of novel anti-HSV drugs.