摘要
[目的]寻找较高活性和杀菌谱更宽的杀菌剂先导化合物并进行结构优化。[方法]设计合成了一类含有取代的苯基(糖基)和嘧啶基哌啶的1,2,3-三唑类化合物。[结果]合成12个结构新颖的含有取代的苯基(糖基)和嘧啶基哌啶的1,2,3-三唑类化合物,结构经过核磁共振氢谱(1H NMR)、高分辨质谱(HMRS)或元素分析确证,并进行杀菌活性测试研究。[结论]杀菌活性测试结果表明:部分目标化合物对对苹果轮纹菌和小麦赤霉菌表现了很好的活性,与百菌清相当。
[Aims] This study aims to search for a novel 1,2,3-triazoles lead with broad-spectrum activity, high potency and then to carry out structural optimization.[Methods] A series of 1,2,3-triazoles containing substituted phenyl(glycosyl)and pyrimidihyl-piperidinyl moiety were designed and synthesized.[Results] Twelve novel 1,2,3-triazoles derivatives were synthesized, their structures were confirmed by1 H NMR, HMRS or elemental analysis.[Conclusions] The fungicidal activities in vitro of target compounds against six fungi indicated that some of the compounds showed good fungicidal activities, which deserves further research.
作者
毛明珍
张媛媛
张晓光
王伦
卫天琪
张建功
王威
宁斌科
李玉新
李正名
MAO Ming-zhen;ZHANG Yuan-yuan;ZHANG Xiao-guang;WANG Lun;WEI Tian-qi;ZHANG Jian-gong;WANG Wei;NING Bin-ke;LI Yu-xin;LI Zheng-Ming(Xi'an Modem Chemistry Research Institute,State Key Laboratory of Fluorine & Nitrogen Chemicals,Xi'an 710065,China;Research Insititute of Elemento-organic Chemistry,State Key Laboratory of Elemento-organic Chemistry,Nankai University,Tianjin 300071,China)
出处
《农药》
CAS
CSCD
北大核心
2019年第8期565-568,共4页
Agrochemicals
关键词
1
2
3-三唑
嘧啶基哌啶
苯基(糖基)
合成
杀菌活性
1,2,3-triazoles
pyrimidihyl-piperidinyl moiety
phenyl (Glycosyl)
synthesis
fungicidal activities
