从柴胡药材质量评价到抗抑郁新药开发的研究思路与策略

Ideas and strategies from quality evaluation of Radix Bupleurum for development of new anti-depressant drugs

中药资源开发与利用是中药现代化的重要内容,中医经典方剂是中药新药研发的重要途径。立足当地中药材资源优势,围绕药材质量评价与中医方剂研究中的关键科学问题,形成以药材质量评价为出发点,以重大需求和科学问题为导向,以代谢组学技术为手段的"中药材质量评价-中医方剂科学内涵挖掘-中药新药研发"研究思路与策略。本文以柴胡药材为例,从药材质量评价、逍遥散基础研究、抗抑郁新药研发等方面系统深入地阐述上述研究思路与策略,为中药现代化发展提供科学依据。

Utilization of traditional Chinese medicine(TCM) resources for pharmaceutical development is an important part of modernization of TCM. The classical TCM prescriptions provide an important insight for developing new drugs. Based on the advantages of local TCM resources, focusing on the key scientific problems in the quality evaluation of medicinal materials and the study of classical prescriptions, this research group takes the quality evaluation of medicinal materials as the starting point. Metabolomics serves as a technical means of"quality evaluation of TCM, to support scientific connotation of classical prescriptions and development of new drugs from TCM. Using Radix Bupleurum as an example, this paper systematically and thoroughly expounds the above research ideas and strategies from the aspects: quality evaluation of medicinal materials, basic research of Xiaoyansan, and research and development of new anti-depressants. This provides the scientific basis for the modernization of TCM.