脊髓损伤神经修复时间窗的相关问题

Certain issues related to time window for neurorestoratology following spinal cord injury

脊髓损伤一直是困扰医学界一大难题,给个人、家庭和社会带来沉重的负担.脊髓损伤后"微环境失衡"是造成神经难以修复的主要原因.脊髓损伤后微环境失衡具有时空特异性,需要精准调控不同时期微环境的变化,明确不同干预措施的治疗时间窗,从而提高治疗效果,减少并发症.目前对脊髓损伤治疗的时间窗界定模糊且笼统.笔者主要介绍脊髓损伤的药物、手术、康复及细胞移植治疗时间窗的最新研究进展,为临床治疗方案的建立提供参考.

Spinal cord injury has long been a major problem difficult to resolve in medicine, which brings heavy burdens to individuals, families and the society. Microenvironment imbalance after spinal cord injury is the main cause for poor nerve restoration. Besides, microenvironment imbalance after spinal cord injury has spatiotemporal specificity. It is necessary to accurately regulate the changes of microenvironment in different periods and clarify the therapeutic time window of different interventions to improve the therapeutic effect and reduce the related complications. However, the therapeutic time window of spinal cord injury is vague and general at present. This article mainly focused on the latest research progress in the time window of drug use, surgical operation, cell transplantation and rehabilitation for spinal cord injury, so as to provide references for clinical therapy strategies.