熊去氧胆酸胶囊联合水飞蓟宾治疗酒精性肝硬化的临床疗效

Clinical effect of ursodesoxycholic acid and silybin in treatment of alcoholic cirrhosis

目的探讨熊去氧胆酸胶囊联合水飞蓟宾治疗酒精性肝硬化的临床疗效。方法选取2016年1月-2018月1月在濮阳市人民医院收治的酒精性肝硬化患者100例,采用随机数字表法分为对照组和观察组,每组各50例,对照组患者仅给予水飞蓟宾,观察组患者给予熊去氧胆酸胶囊联合水飞蓟宾,比较两组患者治疗前后低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、三酰甘油(TG)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)和γ-谷氨酰转肽酶(GGT)、总胆红素(Tbil)、直接胆红素(Dbil)和间接胆红素(Ibil)的水平并比较治疗期间不良反应的发生率。结果治疗后,两组患者的GGT、ALT及AST水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);与对照组相比,观察组患者的GGT、ALT及AST水平均显著降低,差异具有统计学意义(P<0.05)。治疗后,两组患者的Tbil、Dbil及Ibil水平均显著降低,差异具有统计学意义(P<0.05);与对照组相比,观察组患者的Tbil、Dbil及Ibil水平均显著降低,差异具有统计学意义(P<0.05)。治疗后,观察组患者的LDL-C、TC及TG水平均显著降低,而HDL-C显著升高,同组治疗前后比较差异有统计学意义(P<0.05);与对照组相比,观察组患者的LDL-C、TC及TG水平均显著降低,而HDL-C显著升高,差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率(8.00%)显著低于对照组(24.00%),差异具有统计学意义(P<0.05)。结论熊去氧胆酸胶囊联合水飞蓟宾治疗酒精性肝硬化的临床效果较好,能够有效改善患者的血脂水平并提高肝功能。

Objective To investigate the clinical effect of ursodesoxycholic acid and silybin in the treatment of alcoholic cirrhosis.Methods 100 cases alcoholic cirrhosis patients were collected from January 2016 to January 2018 in People’s Hospital of Puyang,according to the random number method divided into control group and observation group, each group has 50 cases, the control group was given silybin, the observation group was given ursodesoxycholic acid and silybin, compared with the level of LDL-C,HDL-C, TC, TG, AST, ALT and GGT, and the incidence of adverse reaction during the treatment. Results Before treatment,compared with the γ-glutamyl endopeptidase, ALT and ASTbetween the control and observation group, the difference was not statistically significant. After treatment, compared with the control group, the γ-glutamyl endopeptidase, ALT and AST both significantly decreased of the observation group, the difference was statistically significant(P < 0.05). After treatment, compared with the control group, the LDL-C, TC, TG, Tbil, Dbil and Ibil both significantly decreased of the observation group, the HDL-C significantly increased, the difference was statistically significant(P < 0.05). The incidence of the adverse drug reaction of the observation group is 4 cases(8.00%), the incidence of the adverse drug reaction of the control group is 12 cases(24.00%), the differences was statistically significant(P < 0.05).Conclusion Ursodesoxycholic acid and silybin has good effect in the treatment of alcoholic cirrhosis, can improve the serum lipid level and liver function.