特布他林联合炎琥宁治疗支原体肺炎患儿的临床效果

Clinical pehydroandrographolide succinate in treatment of children with mycoplasma pneumonia

目的探讨硫酸特布他林注射液联合注射用炎琥宁治疗对支原体肺炎患儿的疗效及血清粒细胞集落刺激因子(GCSF)和单核细胞趋化蛋白1(MCP-1)水平的影响。方法以2016年1月-2017年12月在涟水县人民医院接受治疗的96例支原体感染的肺炎患儿为研究对象,按随机数字表法分为对照组和观察组,每组各48例。对照组患儿静脉滴注注射用炎琥宁,5~10 mg/kg的剂量加入10%葡萄糖溶液55~250 mL中,1次/d;观察组在对照组基础上联合硫酸特布他林注射液进行治疗。观察两组的临床疗效、相关症状及体征消失时间、住院时间以及治疗前后炎性因子、G-CSF、MCP-1的水平变化。结果治疗后,观察组总有效率为93.75%,明显高于对照组的总有效率77.08%,两组比较差异具有统计学意义(P<0.05)。治疗后,观察组的相关症状及体征消失时间以及住院时间明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、干扰素-γ(IFN-γ)、C反应蛋白(CRP)水平显著低于治疗前,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后观察组各炎性因子水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者G-CSF和MCP-1水平显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,观察组患者G-CSF和MCP-1水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论硫酸特布他林注射液联合注射用炎琥宁治疗小儿支原体肺炎可明显改善患者的临床症状,降低炎性因子以及血清G-CSF与MCP-1水平。

Objective To investigate the influence of Terbutaline Sulfate Injection combined with Potassium Sodium Pehydroandroandrographolide Succinate for Injection on the expressions G-CSF and MCP-1 in treatment of children with mycoplasma pneumonia. Methods Children(96 cases) with mycoplasma pneumonia in Lianshui County People’s Hospital from January 2016 to December 2017 were randomly divided into control(48 cases) and observation(48 cases) groups. Children in the control group were given Potassium Sodium Pehydroandroandrographolide Succinate for Injection, 5 - 10 mg/kg added into 10%Glucose Solution 55 - 250 mL, once daily. Observation group was given Terbutaline Sulfate Injection on the basis of control group.Clinical efficacy, disappeared time of related symptoms and signs, hospitalization time, the changes of cytokines, G-CSF and MCP-1 levels before and after treatment in two groups were observed.Results After treatment, the effective rate in observation group was93.75%, which was significantly higher than 77.08% in control group, and there was difference between two groups(P < 0.05).After treatment, the disappeared time of related symptoms and signs, and hospitalization time in the observation group were significantly shorter than those in the control group, and there was difference between two groups(P < 0.05). After treatment, the levels of IL-6, IL-8, IFN-γ, and CRP in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, serum inflammatory factors in the observation group were significantly lower than those in the control group, and there was difference between two groups(P < 0.05). After treatment, the levels of G-CSF and MCP-1 in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the levels of G-CSF and MCP-1 in the observation group were significantly lower than those in the control group, and there was difference between two groups(P < 0.05). Conclusion Terbutaline Sulfate Injection combined with Potassium Sodium Pehydroandroandrographolide Succinate for Injection can effectively improve the clinical efficacy, and decrease the inflammatory factors, G-CSF and MCP-1 levels.