青海省人民医院高同型半胱氨酸血症患者药物治疗方案合理性的探讨

Discussion on rationality of drug treatment scheme for patients with hyperhomocysteinemia in Qinghai People’s Hospital

目的考察青海省人民医院高同型半胱氨酸(Hcy)血症患者药物干预的合理性,为临床合理使用药物治疗高Hcy血症患者提供参考。方法抽取2015年1-3月青海省人民医院诊断为高Hcy血症的住院患者273例,考察Hcy水平与收缩压、舒张压、年龄之间的差异及各科室治疗高Hcy血症药物的合理性。结果 Hcy与年龄、收缩压和舒张压不存在相关性。273例高Hcy血症血症患者基础疾病主要为心血管系统疾病、代谢性疾病及神经系统疾病,占88.67%。273例高Hcy血症患者药物干预率为72.5%。结论青海省人民医院各科使用降Hcy药物存在不合理现象。合理补充叶酸、维生素B6和维生素B12可降低血浆Hcy水平,治疗Hcy合并原发性疾病的临床疗效显著。

Objective To investigate the correlation between homocysteine(Hcy) and blood pressure and age for patients, evaluate the rationality of drug intervention in patients with homocysteinemia in our hospital, and to treat patients with high homocysteine Patients with hematuria to provide a reference.Methods A total of 273 in patients who were diagnosed with hyperhomocysteinemia(HHcy) from January to March 2015 were enrolled in this study. The differences of Hcy levels with systolic blood pressure, diastolic blood pressure and age were investigated. Rationality of Drug Selection for Hyperhomocysteinemia.Results Of the 273 patients, 75 were not treated with drugs, and cardiovascular disease, metabolic diseases and neurological diseases accounted for 88.67%. Systolic blood pressure, diastolic blood pressure were no significant difference between the P values were 0.641, and 0.354. Conclusion Supplementation of small doses of folic acid and vitamin B12 can be used in patients with hyperhomocysteinemia.